ArticleBiomaterials2014
3D printing of composite calcium phosphate and collagen scaffolds for bone regeneration.
Article in Biomaterials, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 245 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
245 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Synthetic Blocks for Bone Regeneration: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2019Pooled it
- The efficacy of using 3D printing models in the treatment of fractures: a randomised clinical trial.BMC musculoskeletal disorders · 2019Trial
- Research hotspots and emerging trends of 3D printing in bone defects: a bibliometric analysis based on Web of Science core collection from 2006 to March 2026.Cell and tissue banking · 2026Article
- Advances in 3D Bioprinting for Scaffold-Based and Scaffold-Free Tissue Engineering and Regenerative Medicine.Gels (Basel, Switzerland) · 2026Review
- Biomimetic bone niche reconstructs proliferation-inhibited and therapy-resistant bone-metastatic prostate cancer.Bioactive materials · 2026Article
- Cranial Defect Reconstruction With Custom 3D-Printed Hydroxyapatite Scaffolds Augmented With rhBMP-2 or Dipyridamole in a Nonhuman Primate Model.Journal of tissue engineering and regenerative medicine · 2026Article
- Organ-Specific Strategies in Bioprinting: Addressing Translational Challenges in the Heart, Liver, Kidney, and Pancreas.Journal of functional biomaterials · 2025Review
- Stimuli-responsive hybrid materials for 4DMaterials today. Bio · 2025Review
- 3D-Printed Cell-Instructive Scaffolds Based onACS biomaterials science & engineering · 2025Article
- Interlacing biology and engineering: An introduction to textiles and their application in tissue engineering.Materials today. Bio · 2025Review
- Overview of porous magnesium-based scaffolds: development, properties and biomedical applications.Materials futures · 2025Review
- 3D-Printed Polymeric Biomaterials for Health Applications.Advanced healthcare materials · 2025Review
- Effect of 3D printing technology-assisted TKA on cartilage tissue in rabbit with knee osteoarthritis.Histology and histopathology · 2024Article
- Engineering of Bioresorbable Polymers for Tissue Engineering and Drug Delivery Applications.Advanced healthcare materials · 2024Review
- 3D bioprinting the human chest wall: Fiction or fact.npj biomedical innovations · 2024Review
- Advances in Bioceramics for Bone Regeneration: A Narrative Review.Biomimetics (Basel, Switzerland) · 2024Review
- Biomedical Composites of Polycaprolactone/Hydroxyapatite for Bioplotting: Comprehensive Interpretation of the Reinforcement Course.Polymers · 2024Article
- Research trends of bone tumor treatment with 3D printing technology from 2013 to 2022: a bibliometric analysis.Discover oncology · 2024Article
- AI-Driven Data Analysis of Quantifying Environmental Impact and Efficiency of Shape Memory Polymers.Biomimetics (Basel, Switzerland) · 2024Review
- Recent Advances in Hydrogel-Based 3D Bioprinting and Its Potential Application in the Treatment of Congenital Heart Disease.Biomolecules · 2024Review
185 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Low temperature 3D printing of calcium phosphate scaffolds holds great promise for fabricating synthetic bone graft substitutes with enhanced performance over traditional techniques. Many design parameters, such as the binder solution properties, have yet to be optimized to ensure maximal biocompatibility and osteoconductivity with sufficient mechanical properties. This study tailored the phosphoric acid-based binder solution concentration to 8.75 wt% to maximize cytocompatibility and mechanical strength, with a supplementation of Tween 80 to improve printing. To further enhance the formulation, collagen was dissolved into the binder solution to fabricate collagen-calcium phosphate composites. Reducing the viscosity and surface tension through a physiologic heat treatment and Tween 80, respectively, enabled reliable thermal inkjet printing of the collagen solutions. Supplementing the binder solution with 1-2 wt% collagen significantly improved maximum flexural strength and cell viability. To assess the bone healing performance, we implanted 3D printed scaffolds into a critically sized murine femoral defect for 9 weeks. The implants were confirmed to be osteoconductive, with new bone growth incorporating the degrading scaffold materials. In conclusion, this study demonstrates optimization of material parameters for 3D printed calcium phosphate scaffolds and enhancement of material properties by volumetric collagen incorporation via inkjet printing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.