ArticleSchizophrenia research2014
Relationship between prefrontal gray matter volumes and working memory performance in schizophrenia: a family study.
Article in Schizophrenia research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Systematic Review of Cognition-Brain Morphology Relationships on the Schizophrenia-Bipolar Disorder Spectrum.Schizophrenia bulletin · 2021Pooled it
- Augmented intermittent theta-burst stimulation of the left dorsolateral prefrontal cortex for cognitive dysfunction in stable-phase schizophrenia: protocol for a randomized, double-blind, sham-controlled trial.Frontiers in psychiatry · 2025Article
- Molecular mechanisms underlying the neural correlates of working memory.BMC biology · 2024Article
- The effect of dopamine replacement therapy on cortical structure in Parkinson's disease.CNS neuroscience & therapeutics · 2024Article
- Genomic patterns linked to gray matter alterations underlying working memory deficits in adults and adolescents with attention-deficit/hyperactivity disorder.Translational psychiatry · 2023Article
- Frontotemporal thalamic connectivity in schizophrenia and schizotypal personality disorder.Psychiatry research. Neuroimaging · 2022Article
- Relationships between cognitive performance, clinical insight and regional brain volumes in schizophrenia.Schizophrenia (Heidelberg, Germany) · 2022Article
- Thalamic Shape Abnormalities Differentially Relate to Cognitive Performance in Early-Onset and Adult-Onset Schizophrenia.Frontiers in psychiatry · 2022Article
- Reduced influence of perceptual context in schizophrenia: behavioral and neurophysiological evidence.Psychological medicine · 2021Article
- Gray matter networks associated with attention and working memory deficit in ADHD across adolescence and adulthood.Translational psychiatry · 2021Article
- Common and Distinct Alterations of Cognitive Function and Brain Structure in Schizophrenia and Major Depressive Disorder: A Pilot Study.Frontiers in psychiatry · 2021Article
- Article
- Abnormal neural functions associated with motor inhibition deficits in schizophrenia and bipolar disorder.Human brain mapping · 2019Article
- Prefrontal dysfunction and a monkey model of schizophrenia.Neuroscience bulletin · 2015Review
- Sex-specific cognitive abnormalities in early-onset psychosis.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Diffuse structural abnormalities in the prefrontal cortex have been reported in both schizophrenia patients and their nonpsychotic biological relatives. Additionally, working memory difficulties have long been documented in schizophrenia patients and have been associated with the genetic liability for the disorder. The present analysis investigated the relationship between prefrontal regional gray matter volumes and two facets of working memory in schizophrenia using a family study. Structural neuroimaging scans provided measurements of rostral middle, superior, and inferior prefrontal cortical gray matter volumes. Participants also completed a spatial working memory task that measured both short-term maintenance and manipulation of material in memory. Both schizophrenia patients and relatives had reduced superior and inferior frontal gray matter volumes. Schizophrenia patients demonstrated a spatial working memory deficit compared to both controls and relatives, with no greater impairment when required to manipulate material. Smaller prefrontal volumes in schizophrenia patients were associated with worse working memory performance. These relationships were absent in the nonpsychotic relatives and controls. Despite normative behavioral performance, nonpsychotic relatives demonstrated abnormalities in brain structure similar to those found in schizophrenia patients. Manipulation abilities were not more impaired than maintenance in schizophrenia patients. Consistent with other neuroimaging research, our results suggest that direct measures of the underlying biology may be more sensitive to the effects of the genetic liability for schizophrenia than behavioral measures.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.