ArticleJournal of biomechanics2014
The influence of computational strategy on prediction of mechanical stress in carotid atherosclerotic plaques: comparison of 2D structure-only, 3D structure-only, one-way and fully coupled fluid-structure interaction analyses.
Article in Journal of biomechanics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Combining Computational Fluid Dynamics, Structural Analysis, and Machine Learning to Predict Cerebrovascular Events: A Mild ML Approach.Diagnostics (Basel, Switzerland) · 2024Article
- Haemodynamic Effects on the Development and Stability of Atherosclerotic Plaques in Arterial Blood Vessel.Interdisciplinary sciences, computational life sciences · 2023Article
- Finite element analysis in clinical patients with atherosclerosis.Journal of the mechanical behavior of biomedical materials · 2022Article
- Automated finite element approach to generate anatomical patient-specific biomechanical models of atherosclerotic arteries from virtual histology-intravascular ultrasound.Frontiers in medical technology · 2022Article
- Multi-patient study for coronary vulnerable plaque model comparisons: 2D/3D and fluid-structure interaction simulations.Biomechanics and modeling in mechanobiology · 2021Article
- Stress distribution analysis in healthy and stenosed carotid artery models reconstructed from in vivo ultrasonography.Ultrasonography (Seoul, Korea) · 2021Article
- Ex Vivo Evaluation of IVUS-VH Imaging and the Role of Plaque Structure on Peripheral Artery Disease.Medicine in novel technology and devices · 2020Article
- Consideration of stiffness of wall layers is decisive for patient-specific analysis of carotid artery with atheroma.PloS one · 2020Article
- Stress-Relaxation and Cyclic Behavior of Human Carotid Plaque Tissue.Frontiers in bioengineering and biotechnology · 2020Article
- [Numerical simulation of the effect of virtual stent release pose on the expansion results].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2018Article
- Stress analysis of fracture of atherosclerotic plaques: crack propagation modeling.Medical & biological engineering & computing · 2017Article
- High Structural Stress and Presence of Intraluminal Thrombus Predict Abdominal Aortic Aneurysm 18F-FDG Uptake: Insights From Biomechanics.Circulation. Cardiovascular imaging · 2016Article
- 3D MRI-based multicomponent thin layer structure only plaque models for atherosclerotic plaques.Journal of biomechanics · 2016Article
- Role of biomechanical forces in the natural history of coronary atherosclerosis.Nature reviews. Cardiology · 2016Review
- Mechanical response of cardiovascular stents under vascular dynamic bending.Biomedical engineering online · 2016Article
- The influence of constitutive law choice used to characterise atherosclerotic tissue material properties on computing stress values in human carotid plaques.Journal of biomechanics · 2015Article
- Subject-Specific Fully-Coupled and One-Way Fluid-Structure Interaction Models for Modeling of Carotid Atherosclerotic Plaques in Humans.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- Influence of material property variability on the mechanical behaviour of carotid atherosclerotic plaques: a 3D fluid-structure interaction analysis.International journal for numerical methods in biomedical engineering · 2015Article
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Authors and funding
6 authors.
Funding
Abstract
backgroundCompositional and morphological features of carotid atherosclerotic plaques provide complementary information to luminal stenosis in predicting clinical presentations. However, they alone cannot predict cerebrovascular risk. Mechanical stress within the plaque induced by cyclical changes in blood pressure has potential to assess plaque vulnerability. Various modeling strategies have been employed to predict stress, including 2D and 3D structure-only, 3D one-way and fully coupled fluid-structure interaction (FSI) simulations. However, differences in stress predictions using different strategies have not been assessed.
methodsMaximum principal stress (Stress-P1) within 8 human carotid atherosclerotic plaques was calculated based on geometry reconstructed from in vivo computerized tomography and high resolution, multi-sequence magnetic resonance images. Stress-P1 within the diseased region predicted by 2D and 3D structure-only, and 3D one-way FSI simulations were compared to 3D fully coupled FSI analysis.
resultsCompared to 3D fully coupled FSI, 2D structure-only simulation significantly overestimated stress level (94.1 kPa [65.2, 117.3] vs. 85.5 kPa [64.4, 113.6]; median [inter-quartile range], p=0.0004). However, when slices around the bifurcation region were excluded, stresses predicted by 2D structure-only simulations showed a good correlation (R(2)=0.69) with values obtained from 3D fully coupled FSI analysis. 3D structure-only model produced a small yet statistically significant stress overestimation compared to 3D fully coupled FSI (86.8 kPa [66.3, 115.8] vs. 85.5 kPa [64.4, 113.6]; p<0.0001). In contrast, one-way FSI underestimated stress compared to 3D fully coupled FSI (78.8 kPa [61.1, 100.4] vs. 85.5 kPa [64.4, 113.7]; p<0.0001).
conclusionsA 3D structure-only model seems to be a computationally inexpensive yet reasonably accurate approximation for stress within carotid atherosclerotic plaques with mild to moderate luminal stenosis as compared to fully coupled FSI analysis.
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