ArticleBMC pediatrics2014
Pressure- versus volume-limited sustained inflations at resuscitation of premature newborn lambs.
Article in BMC pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Improving Newborn Respiratory Outcomes With a Sustained Inflation: A Systematic Narrative Review of Factors Regulating Outcome in Animal and Clinical Studies.Frontiers in pediatrics · 2020Pooled it
- Sustained lung inflation in late preterm infants: a randomized controlled trial.Journal of perinatology : official journal of the California Perinatal Association · 2016Trial
- Sustained Aeration of Infant Lungs (SAIL) trial: study protocol for a randomized controlled trial.Trials · 2015Trial
- Utility of electrical impedance tomography to measure neonatal pulmonary circulation changes: a lamb study.Pediatric research · 2026Article
- Aeration strategy at birth does not impact carotid haemodynamics in preterm lambs.Pediatric research · 2023Article
- Sustained Inflation of Infant Lungs: From Bench to Bedside and Back Again.American journal of respiratory and critical care medicine · 2019Article
- Gestational Age Influences the Early Microarchitectural Changes in Response to Mechanical Ventilation in the Preterm Lamb Lung.Frontiers in pediatrics · 2019Article
- Plasma proteomics reveals gestational age-specific responses to mechanical ventilation and identifies the mechanistic pathways that initiate preterm lung injury.Scientific reports · 2018Article
- Lung Recruitment Strategies During High Frequency Oscillatory Ventilation in Preterm Lambs.Frontiers in pediatrics · 2018Article
- Time to lung aeration during a sustained inflation at birth is influenced by gestation in lambs.Pediatric research · 2017Article
- Intratracheal atomized surfactant provides similar outcomes as bolus surfactant in preterm lambs with respiratory distress syndrome.Pediatric research · 2016Article
- The interrelationship of recruitment maneuver at birth, antenatal steroids, and exogenous surfactant on compliance and oxygenation in preterm lambs.Pediatric research · 2016Article
- Selection of Reference Genes for Gene Expression Studies related to lung injury in a preterm lamb model.Scientific reports · 2016Article
- Distending Pressure Did Not Activate Acute Phase or Inflammatory Responses in the Airways and Lungs of Fetal, Preterm Lambs.PloS one · 2016Article
- Pressure-limited sustained inflation vs. gradual tidal inflations for resuscitation in preterm lambs.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Neonatal resuscitation: evolving strategies.Maternal health, neonatology and perinatology · 2015Article
- Sustained inflation at birth did not alter lung injury from mechanical ventilation in surfactant-treated fetal lambs.PloS one · 2014Article
Corrections and comments
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Authors and funding
10 authors at 7 institutions in 2 countries.
Funding
Abstract
backgroundSustained inflations (SI) are advocated for the rapid establishment of FRC after birth in preterm and term infants requiring resuscitation. However, the most appropriate way to deliver a SI is poorly understood. We investigated whether a volume-limited SI improved the establishment of FRC and ventilation homogeneity and reduced lung inflammation/injury compared to a pressure-limited SI.
methods131 d gestation lambs were resuscitated with either: i) pressure-limited SI (PressSI: 0-40 cmH2O over 5 s, maintained until 20 s); or ii) volume-limited SI (VolSI: 0-15 mL/kg over 5 s, maintained until 20 s). Following the SI, all lambs were ventilated using volume-controlled ventilation (7 mL/kg tidal volume) for 15 min. Lung mechanics, regional ventilation distribution (electrical impedance tomography), cerebral tissue oxygenation index (near infrared spectroscopy), arterial pressures and blood gas values were recorded regularly. Pressure-volume curves were performed in-situ post-mortem and early markers of lung injury were assessed.
resultsCompared to a pressure-limited SI, a volume-limited SI had increased pressure variability but reduced volume variability. Each SI strategy achieved similar end-inflation lung volumes and regional ventilation homogeneity. Volume-limited SI increased heart-rate and arterial pressure faster than pressure-limited SI lambs, but no differences were observed after 30 s. Volume-limited SI had increased arterial-alveolar oxygen difference due to higher FiO2 at 15 min (p = 0.01 and p = 0.02 respectively). No other inter-group differences in arterial or cerebral oxygenation, blood pressures or early markers of lung injury were evident.
conclusionWith the exception of inferior oxygenation, a sustained inflation targeting delivery to preterm lambs of 15 mL/kg volume by 5 s did not influence physiological variables or early markers of lung inflammation and injury at 15 min compared to a standard pressure-limited sustained inflation.
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