Evidence map›Paper›PMID 24529139›Full record

ArticleAtherosclerosis2014

Leukotriene haplotype × diet interaction on carotid artery hypertrophy and atherosclerosis in American Indians: the Strong Heart Family Study.

Jinying Zhao, Mary J Roman, Richard B Devereux, Fawn Yeh, Ying Zhang, Karin Haack, Lyle G Best, Shelley A Cole, Elisa T Lee, Barbara V Howard

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Atherosclerosis, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Jinying ZhaoDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA. Electronic address: jzhao5@tulane.edu.
Mary J RomanWeill Cornell Medical College, New York, NY, USA.
Richard B DevereuxWeill Cornell Medical College, New York, NY, USA.
Fawn YehCenter for American Indian Health Research, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Ying ZhangCenter for American Indian Health Research, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Karin HaackTexas Biomedical Research Institute, San Antonio, TX, USA.
Lyle G BestMissouri Breaks Industries Research Inc, Timber Lake, SD, USA.
Shelley A ColeTexas Biomedical Research Institute, San Antonio, TX, USA.
Elisa T LeeCenter for American Indian Health Research, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Barbara V HowardMedStar Health Research Institute Hyattsville, MD and Georgetown and Howard Universities Centers for Translational Sciences, Washington, DC, USA.
University of Oklahoma Health Sciences Center · USCornell University · USTexas Biomedical Research Institute · USMedStar Health · USMissouri Breaks Industries Research (United States) · USTulane University · US

Funding

The Strong Heart Study, Phase VU01HL041654 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI LEE, ELISA TAN · 1988 to 2013
$19.2M
CARDIOVASCULAR DISEASE IN THE PIMA INDIANSU01HL041642 · NHLBI · MEDSTAR RESEARCH INSTITUTE · PI HOWARD, BARBARA V · 1988 to 2013
$12.6M
STRONG HEART FAMILY STUDYU01HL065520 · NHLBI · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI COLE, SHELLEY A · 2000 to 2011
$8.9M
CARDIOVASCULAR DISEASE IN SIOUX INDIANSU01HL041652 · NHLBI · U.S. PHS INDIAN HEALTH SERVICE · PI BEST, LYLE G · 1988 to 2013
$7.9M
CARDIOVASCULAR EVALUATION--STRONG HEART STUDY PHASE IVU01HL065521 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI DEVEREUX, RICHARD B · 2000 to 2013
$4.3M
CVD in American Indians Genetics CenterR01HL109301 · NHLBI · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI COLE, SHELLEY A · 2013 to 2018
$3.2M
Telomere attrition and diabetes risk in American IndiansR01DK091369 · NIDDK · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI HE, JIANG · 2011 to 2014
$1.1M
Biological Aging Mitrochondrial Variants and Coronary Artery DiseaseK01AG034259 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI ZHAO, JINYING · 2009 to 2012
$525k
Genetic Variations in the HPA Axis and Comorbidity of Depression and CardiovasculR21HL092363 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI LEE, ELISA TAN · 2009 to 2010
$403k
MOLECULAR AND BIOCHEMICAL GENETICS LABORATORY RENOVATIONC06RR013556 · NCRR · SOUTHWEST FOUNDATION FOR BIOMEDICAL RES · PI SHADE, ROBERT E · 1998 to 1998
–
NCRR NIH HHS C06 RR013556NHLBI NIH HHS R01 HL109301NHLBI NIH HHS R21 HL092363NHLBI NIH HHS R21HL092363NHLBI NIH HHS U01 HL041642NHLBI NIH HHS U01 HL041652NHLBI NIH HHS U01 HL041654NHLBI NIH HHS U01 HL065520NHLBI NIH HHS U01 HL065521NHLBI NIH HHS U01HL41642NHLBI NIH HHS U01HL41652NHLBI NIH HHS U01HL41654NHLBI NIH HHS U01HL65520NHLBI NIH HHS U01HL65521NIA NIH HHS K01 AG034259NIA NIH HHS K01AG034259NIDDK NIH HHS R01 DK091369NIDDK NIH HHS R01DK091369
6 · The paper itself

Abstract

objectiveGene × diet interaction plays an important role in atherosclerosis, an inflammatory disorder. Leukotrienes are the most potent inflammatory mediators, and genetic variants encoding leukotriene genes have been implicated in atherosclerosis. This study tests nutrigenetic interaction of a previously defined leukotriene haplotype on carotid artery hypertrophy and atherosclerosis in American Indians.

methodsThis study included 3402 American Indians participating in the Strong Heart Family Study (SHFS). Carotid artery measurements, including intima-media thickness (IMT), vascular mass, and plaque, were assessed using ultrasound. Eleven tagSNPs in the leukotriene A4 hydrolase (LTA4H) gene were genotyped in all subjects. Main haplotype effect and haplotype × diet interaction were examined by generalized estimating equation, adjusting for known risk factors.

resultsThere was no significant main effect of haplotype or diet on any of the carotid artery measures. However, a previously defined LTA4H haplotype, called HapE, significantly interacted with dietary intake of n-3 and n-6 fatty acids on both IMT (P(HapE × n3) = 0.018, P(HapE × n6) = 0.040) and vascular mass (P(HapE × n3) = 0.012, P(HapE × n6) = 0.018), but not plaque. The direction of this nutrigenetic interaction on IMT was consistent with that reported in a recent study of Caucasian twins.

conclusionDietary intake of polyunsaturated fatty acids significantly modifies the effect of a leukotriene haplotype on carotid artery hypertrophy but not atherosclerosis in American Indians, independent of established cardiovascular risk factors. Replication of nutrigenetic interaction in two distinct ethnic groups suggests the robustness and generalizability of our findings to diverse populations.

Indexed as

AdultCarotid ArteriesCarotid Artery DiseasesCarotid Intima-Media ThicknessDietary FatsEpoxide HydrolasesFatty Acids, Omega-3Fatty Acids, Omega-6FemaleGenotypeHaplotypesHumansHypertrophyIndians, North AmericanMaleMiddle AgedDietary FatsEpoxide HydrolasesFatty Acids, Omega-3Fatty Acids, Omega-6leukotriene A4 hydrolaseAmerican IndiansCarotid atherosclerosisGene–diet interactionLeukotriene haplotype

Identifiers

PMID24529139
PMCPMC3932307
OpenAlexW2169135541

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.