Evidence map›Paper›PMID 24529046›Full record

ArticleJournal of psychosomatic research2014

Modulation of intracortical inhibition in response to acute psychosocial stress is impaired among individuals with chronic neck pain.

Ryan J Marker, Jennifer L Stephenson, Benzi M Kluger, Douglas Curran-Everett, Katrina S Maluf

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychosomatic research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 21 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Relationship between Sleep Bruxism, Perceived Stress, and Coping Strategies.International journal of environmental research and public health · 2019
    Article
  6. Article
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  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ryan J MarkerRehabilitation Science Program, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Jennifer L StephensonClinical Science Program, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Benzi M KlugerDepartment of Neurology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Douglas Curran-EverettDivision of Biostatistics and Bioinformatics, National Jewish Health, Denver, CO, USA; Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Katrina S MalufRehabilitation Science Program, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Physical Therapy Program, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. Electronic address: Katrina.Maluf@ucdenver.edu.
University of Colorado Anschutz Medical Campus · USUniversity of Colorado Denver · US

Funding

Colorado Clinical and Translational Science Institute (KL2)KL2RR025779 · NCRR · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2008 to 2011
$2.2M
Stress-Evoked Muscle Activity in Occupational MyalgiaR01AR056704 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI MONROE, KATRINA S. · 2010 to 2013
$1.2M
NCRR NIH HHS KL2 RR025779NCRR NIH HHS KL2RR025779NIAMS NIH HHS R01 AR056704NIAMS NIH HHS R01AR056704
6 · The paper itself

Abstract

objectivePsychosocial stress has been associated with a variety of chronic pain disorders although the mechanisms responsible for this relationship are unknown. The purpose of this study was to compare the excitability of intracortical and corticospinal pathways to the trapezius muscle in individuals with and without chronic neck pain during exposure to low and high levels of psychosocial stress.

methodsSingle and paired-pulse transcranial magnetic stimulation was used to assess motor evoked potentials (MEPs) and short-interval intracortical inhibition (SICI) during mental math performed in the presence and absence of social evaluative threat.

resultsAll participants demonstrated higher amplitude MEPs in the high stress compared to the low stress condition (p < 0.01). Participants with chronic neck pain had significantly greater SICI than healthy participants in the low stress condition (p = 0.03). During exposure to the stressor, healthy participants showed an increase in SICI, whereas participants with neck pain showed no change (group difference for change in SICI, p < 0.01).

conclusionsThese findings suggest that individuals with chronic neck pain inhibit motor output to the trapezius in the presence of minor stressors, and are unable to compensate for additional stress-evoked increases in corticospinal excitability through further modulation of SICI. This observation has potential implications for the management of patients who have difficulty relaxing painful muscles during times of stress.

Indexed as

AdultChronic PainElectromyographyEvoked Potentials, MotorFemaleHumansMaleMiddle AgedMotor CortexNeck PainNeural InhibitionPyramidal TractsStress, PsychologicalTranscranial Magnetic StimulationAnxietyElectromyographyMotor cortexMotor evoked potentialTranscranial magnetic stimulationTrapezius muscle

Identifiers

PMID24529046
PMCPMC9288141
OpenAlexW1982224254

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.