ArticleDiabetology & metabolic syndrome2014
Comparison of salivary and plasma adiponectin and leptin in patients with metabolic syndrome.
Article in Diabetology & metabolic syndrome, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- Integrated neuromuscular training intervention applied in schools induces a higher increase in salivary high molecular weight adiponectin and a more favorable body mass index, cardiorespiratory fitness and muscle strength in children as compared to the traditional physical education classes.Frontiers in public health · 2024Trial
- High physical activity is associated with decreased fungiform papillae area and number, elevated sucrose recognition thresholds, and increased IL-6 levels: an observational human study.Nutrition & metabolism · 2025Article
- Article
- Oral Findings, Salivary Copper, Magnesium, and Leptin in Type II Diabetic Patients in Relation to OralInternational journal of microbiology · 2024Article
- Correlation of serum biochemical parameters and saliva pH in healthy individuals.Saudi journal of biological sciences · 2023Article
- Impact of Intermittent Fasting on Metabolic Syndrome and Periodontal Disease-A Suggested Preventive Strategy to Reduce the Public Health Burden.International journal of environmental research and public health · 2022Review
- Salivary Adipokine and Cytokine Levels as Potential Markers for the Development of Obesity and Metabolic Disorders.International journal of molecular sciences · 2021Review
- Association between metabolic syndrome and periodontitis: The role of lipids, inflammatory cytokines, altered host response, and the microbiome.Periodontology 2000 · 2021Review
- Evaluation of Salivary Leptin Levels and Its Correlation with Class I, Class II, and Class III Facial Skeletal Pattern: A Prefatory Study.European journal of dentistry · 2021Article
- Degree of Agreement Between Infant Serum and Salivary Concentration of Leptin and Adiponectin and Its Association With Infants' Feeding.Biological research for nursing · 2021Article
- Poor Oral Hygiene and High Levels of Inflammatory Cytokines in Saliva Predict the Risk of Overweight and Obesity.International journal of environmental research and public health · 2020Article
- The Clinical Utility of Salivary Biomarkers in the Identification of Type 2 Diabetes Risk and Metabolic Syndrome.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Review
- Salivary Leptin Level in Young Adult Males and its Association with Anthropometric Measurements, Fat Distribution and Muscle Mass.European endocrinology · 2018Review
- Salivary and serum adiponectin and C-reactive protein levels in acute myocardial infarction related to body mass index and oral health.Journal of periodontal research · 2017Article
- Association between Salivary Leptin Levels and Taste Perception in Children.Journal of nutrition and metabolism · 2017Article
- Article
- Saliva as a non-invasive diagnostic tool for inflammation and insulin-resistance.World journal of diabetes · 2014Article
- Peptides and food intake.Frontiers in endocrinology · 2014Review
- Assessment of serum and salivary adiponectin levels in newly diagnosed Type II diabetes mellitus patients.Journal of oral and maxillofacial pathology : JOMFPArticle
- The Interplay of Salivary Leptin, Taste Perception, and Dental Caries in Adolescent Girls: A Cross-Sectional Analysis Across Body Mass Index Categories.Journal of International Society of Preventive & Community DentistryArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe relationship of saliva with plasma protein levels makes saliva an attractive diagnostic tool. Plasma levels of adiponectin and leptin in healthy individuals or diabetes mellitus patients have been previously reported. Nevertheless, salivary levels of these adipocytokines in patients with metabolic syndrome (MS) have never been investigated. This study was aimed to determine adiponectin and leptin levels in saliva and plasma from patients with metabolic syndrome, and evaluate any correlation of these levels with MS.
methodsForty-six healthy and 82 MS patients were enrolled. Demographic data and blood biochemistries were recorded. Saliva and plasma adiponectin and leptin levels were analyzed by enzyme-linked immunosorbent assay (ELISA).
resultsAdiponectin and leptin were higher in plasma than in saliva (p < .001). Plasma adiponectin was decreased and plasma leptin increased in patients with MS (p < .001). Salivary adiponectin and salivary leptin were not different between healthy subjects and MS patients (p = .619 and p = .523). Correlation between salivary and plasma adiponectin showed significant association (r = .211, p = .018) while salivary and plasma leptin had no correlation (r = -.161, p = .069). Significant correlation was observed between the salivary adiponectin/salivary leptin ratio and plasma adiponectin (r = .371, p < .001), but not with any component of MS. Increased triglyceride and waist circumference were associated with risk of having a low level of plasma adiponectin (OR = 1.009; 95% CI 1.002-1.015 and OR = 1.125; 95% CI 1.029-1.230). For leptin, body mass index and high-density lipoprotein cholesterol (HDL-C) were associated with a high level of plasma leptin (OR = 1.621; 95% CI 1.212-2.168 and OR = .966; 95% CI .938-.996). The OR for MS as predicted by plasma adiponectin was .928 (95% CI .881-.977).
conclusionsThis study showed that salivary adiponectin and leptin do not correlate with MS. Although correlation between salivary and plasma adiponectin was observed, no association with MS was observed. Only plasma adiponectin may be useful for the prediction of MS.
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Registered trials
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