ArticleBMC nephrology2014
A case of podocytic infolding glomerulopathy with multiple myeloma.
Article in BMC nephrology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Podocytic infolding glomerulopathy: two new cases with connective tissue disease and literature review.Clinical rheumatology · 2019Pooled it
- Histopathological Examination of Clustering Microspheres and Podocyte Infolding in the Glomerular Basement Membrane Using Low-vacuum Scanning Electron Microscopy.Internal medicine (Tokyo, Japan) · 2026Article
- Podocyte Infolding Glomerulopathy: A Special Morphology of Podocyte Injury Caused by Heterogeneous Diseases.Kidney international reports · 2023Article
- Integrated Chinese and Western medicine in the treatment of a patient with podocyte infolding glomerulopathy: A case report.World journal of clinical cases · 2023Article
- Podocyte Infolding Glomerulopathy: A Case Series Report and Literature Review.Journal of clinical medicine · 2023Article
- Podocyte Infolding Glomerulopathy, First Case Report From North America.Canadian journal of kidney health and disease · 2021Article
- Case report: a peculiar glomerulopathy in a patient suffering from nephrotic syndrome.BMC nephrology · 2019Article
- Monoclonal gammopathy of renal significance (MGRS): the characteristics and significance of a new meta-entity.International urology and nephrology · 2017Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPodocytic infolding glomerulopathy (PIG) is a recently described condition causing rare pathological changes to the glomeruli, and has attracted considerable attention. PIG is characterized by specific changes to the thickened glomerular basement membrane (GBM), including microspheres, microtubular structures, and podocytic infolding. Only a small number of cases of PIG have been reported. The clinical features and pathogenesis of this condition are still unclear. To elucidate the characteristics of this glomerulopathy, it is necessary to accumulate information from reported cases. We present here the first reported case of PIG with multiple myeloma. CASE PRESENTATION: A 79-year-old Japanese man was admitted to his local hospital with proteinuria, hypergammaglobulinemia, hypoalbuminemia, and kidney dysfunction. Laboratory tests revealed monoclonal IgG(λ) M proteins in the serum and Bence-Jones proteins in the urine. Bone marrow aspiration showed monoclonal plasma cell proliferation, indicating a diagnosis of multiple myeloma. Renal biopsy was performed to determine the cause of the proteinuria and kidney dysfunction. Histological examination of the biopsy specimen showed glomeruli with an irregularly thickened GBM and bubble-like structures in the capillary walls. Immunofluorescence staining did not show glomerular deposition of immunoglobulins, light chains, or complement components. Congo red staining did not show amyloid deposition. Electron microscopy showed an irregularly thickened GBM with unusual structures in the glomerular capillary walls including podocytic infolding and microspheres, suggesting PIG. There were no electron-dense deposits in the GBM, while various findings indicating podocyte injury were detected.
conclusionWe present here the first reported case of PIG in a patient with multiple myeloma. The mechanisms underlying the development of PIG in multiple myeloma are unknown, but may be associated with podocyte injury.
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