ArticleThe Journal of clinical investigation1988
Interleukin 1 stimulates T lymphocytes to produce granulocyte-monocyte colony-stimulating factor.
Article in The Journal of clinical investigation, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 149 citations in OpenAlex.
- Cytokine storm and COVID-19: a chronicle of pro-inflammatory cytokines.Open biology · 2020Review
- The peripheral myeloid expansion driven by murine cancer progression is reversed by radiation therapy of the tumor.PloS one · 2013Article
- IL-1 and T Helper Immune Responses.Frontiers in immunology · 2013Article
- Reduced IL-1 production in adolescents with mite antigen asthma in remission.Clinical and experimental immunology · 1998Article
- Production of granulocyte-macrophage colony-stimulating factor by T cells is regulated by B7 and IL-1 beta.Immunology · 1996Article
- The effects of granulocyte-macrophage colony-stimulating factor on tumour-infiltrating lymphocytes from renal cell carcinoma.British journal of cancer · 1995Article
- Cytokines and pulmonary fibrosis.Thorax · 1993Review
- Granulocyte-macrophage colony-stimulating factor in the sera of patients with aplastic anemia.The Clinical investigator · 1993Article
- Effects of granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-2, interferon-gamma (IFN-gamma), tumour necrosis factor-alpha (TNF-alpha) and IL-6 on the production of immunoreactive IL-1 and TNF-alpha by human monocytes.Clinical and experimental immunology · 1991Article
- Interleukin-1, immune activation pathways, and different mechanisms in osteoarthritis and rheumatoid arthritis.Annals of the rheumatic diseases · 1991Review
- Article
- The biological activities of interleukin-1.Blut · 1989Review
- Interleukin-2 and interferon-gamma recruit different subsets of human peripheral blood monocytes to secrete interleukin-1 beta and tumour necrosis factor-alpha.Clinical and experimental immunology · 1989Article
- Protracted anemia associated with chronic, relapsing systemic inflammation induced by arthropathic peptidoglycan-polysaccharide polymers in rats.Infection and immunity · 1989Article
- Polypeptides controlling hematopoietic cell development and activation. I. In vitro results.Blut · 1989Review
Corrections and comments
- Retraction · 2003-10-15Falsification/Fabrication of Data · Investigation by Company/Institution · Investigation by Third Party ·
- RetractedRetraction.2003
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
T lymphocytes are thought to cooperatively interact with monocytes to produce colony-stimulating factors (CSF). However, little is known about monocyte-mediated signals leading to CSF-secretion by T lymphocytes, although soluble monocyte products have been implicated. We have employed monoclonal antibody anti-T3B covalently coupled to CnBr-activated Sepharose 4B beads, to show that multimeric ligation of T cell antigen receptor leads to T cell receptiveness to interleukin 1 (IL-1), as indicated by T cell production of CSF, which induces growth of myeloid progenitor cells into neutrophil, eosinophil, and monocyte colonies. To investigate the molecular basis of these findings, total RNA was extracted from T3B Sepharose-primed and IL-1-stimulated T lymphocytes and probed for granulocyte-monocyte-CSF (GM-CSF), granulocyte-CSF (G-CSF), and monocyte-CSF (M-CSF) mRNA. GM-CSF, but not G-CSF or M-CSF, messages were detected. Nuclear "run on" assays revealed that IL-1 action is effective primarily at the level of GM-CSF gene transcription. These results suggest a previously unrecognized role of IL-1 in the regulation of GM-CSF secretion by T cells.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.