ArticleHistochemistry1988
Neuropeptide (neuropeptide Y, neurotensin, vasoactive intestinal polypeptide, substance P, calcitonin gene-related peptide, somatostatin) immunohistochemistry and ultrastructure of renal nerves.
Article in Histochemistry, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 82 citations in OpenAlex.
- Afferent innervation of the kidney: projections to and processing in the central nervous system.Frontiers in physiology · 2025Review
- Neuroimmune interplay in kidney health and disease: Role of renal nerves.Autonomic neuroscience : basic & clinical · 2023Review
- Sympathetic innervation of the mouse kidney and liver arising from prevertebral ganglia.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Neurogenic substance P-influences on action potential production in afferent neurons of the kidney?Pflugers Archiv : European journal of physiology · 2021Article
- Neurogenic tachykinin mechanisms in experimental nephritis of rats.Pflugers Archiv : European journal of physiology · 2020Article
- Cardiac magnetic resonance assessment of central and peripheral vascular function in patients undergoing renal sympathetic denervation as predictor for blood pressure response.Clinical research in cardiology : official journal of the German Cardiac Society · 2018Article
- Renal sympathetic denervation in therapy resistant hypertension - pathophysiological aspects and predictors for treatment success.World journal of cardiology · 2016Review
- Renal denervation--implications for chronic kidney disease.Nature reviews. Nephrology · 2014Review
- Angiotensinergic innervation of the kidney: present knowledge and its significance.Current hypertension reports · 2013Review
- Neurotensin attenuates the reduction in alcohol drinking produced by angiotensin II.Psychopharmacology · 1996Article
- Sympathetic and sensory innervation of the urinary tract in young adult and aged rats: a semi-quantitative histochemical and immunohistochemical study.The Histochemical journal · 1994Article
- The rat renal nerves during development.Anatomy and embryology · 1993Article
- The renal nerves in the newborn rat.Pediatric nephrology (Berlin, Germany) · 1993Article
- Distribution patterns and coexistence of neurohormonal peptides (ANP, BNP, NPY, SP, CGRP, enkephalins) in chromaffin cells and nerve fibers of the anuran adrenal organ.Cell and tissue research · 1992Article
- Effects of neuropeptide-Y on renal function and its interaction with sympathetic stimulation in conscious dogs.The Journal of physiology · 1991Article
- Differential effect of neuropeptide-Y on membrane potential of cells in renal arterioles of the hydronephrotic mouse.The Journal of physiology · 1991Article
- Vasoactive intestinal peptide stimulation of human renal adenylate cyclase in vitro.The Journal of physiology · 1990Article
- Localisation and characterisation of functional vasoactive intestinal peptide receptors in feline kidney.Pflugers Archiv : European journal of physiology · 1990Article
- Calcitonin gene products and the kidney.Klinische Wochenschrift · 1989Review
- Vasoactive intestinal peptide stimulation of renal adenylate cyclase and antagonism by (4Cl-D-Phe6Leu17)VIP.Pflugers Archiv : European journal of physiology · 1989Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With the use of several region-specific antisera and the peroxidase-antiperoxidase (PAP) technique, several regulatory polypeptides were localized in nerves of the kidney. Neuropeptide Y (NPY)- immunoreactivity (IR), neurotensin (NT)-IR and vasoactive intestinal polypeptide (VIP)-IR occurred at high densities in all segments of the renal arterial system forming a perivascular plexus. Furthermore, NT-IR nerves were particularly frequent at the juxtaglomerular apparatus (JGA). Calcitonin gene-related peptide (CGRP)-IR was mainly concentrated in nerves supplying the hilus arteries and the JGA. Substance P (SP)-IR was predominantly found in large varicosities close to large renal arterial vessels and in the vicinity of the JGA. Somatostatin (SOM)-IR was only observed in single varicosities located at the media-adventitia border of large renal hilus arteries. The peptidergic nerves are correlated to their ultrastructural counterpart. In addition, the distribution patterns and the frequency of the different types of renal peptidergic nerve fibres are evaluated and compared. The functional role of these neuropeptides and their origin within the efferent branch of this part of the peripheral autonomic nervous system is discussed. Furthermore, the implication of some of the neuropeptides studied in afferent renal innervation is also substantiated.
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