ArticleHistochemistry1988
Computer-assisted morphometric study of the innervation of the guinea pig heart.
Article in Histochemistry, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- A quantitative study of nerve distribution in the conduction system of the guinea pig heart.Journal of anatomy · 1996Article
- Heart innervation after ligation of the left anterior descending coronary artery (LAD).Histochemistry · 1989Article
- Interzonal and intrazonal heterogeneities in the renin status of the preglomerular arterioles in five species.Histochemistry · 1988Article
- Significance of cardiac innervation on spontaneous ventricular arrhythmias elicited by left stellate ganglion stimulation in dogs 4 days after myocardial infarction: comparison of two experimental models.Basic research in cardiologyArticle
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A computer-assisted method is introduced for the morphometric analysis of immunoreactive markers of the innervation of the heart, such as synaptophysin, neuropeptide Y (NPY), neurotensin (NT), substance P (SP), and calcitonin gene-related peptide (CGRP). Video images of stained sections were digitalized and the area density (AD) of the immunoreactive structures was measured by discrimination for grey levels within the myocardium of the right atrium, the perivascular region of epicardial arteries, and the trunk of the bundle of His. Synaptophysin immunoreactivity (IR), which served as a marker for presynaptic vesicles, indicated a dense innervation of the conductive system (AD 1.5241). Marked differences in the pattern of distribution were found between the neuropeptides. The AD of NPY-IR (0.5073) and SP-IR (0.1352) was highest in the perivascular tissue, while NT-IR (0.1628) and CGRP-IR (0.5161) exhibited maximal values in the bundle of His. The computer-assisted morphometric measurement of the AD of immunoreactive markers is suggested to be a suitable method for quantitative studies of the innervation of the heart under normal and experimental conditions.
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Registered trials
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