ArticlePhotomedicine and laser surgery2014
Multiresistant strains are as susceptible to photodynamic inactivation as their naïve counterparts: protoporphyrin IX-mediated photoinactivation reveals differences between methicillin-resistant and methicillin-sensitive Staphylococcus aureus strains.
Article in Photomedicine and laser surgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Investigating the Efficacy of Various Photosensitizers and Irradiation Strategies in Antimicrobial Photodynamic Inactivation on Different Types of Microbes.International journal of molecular sciences · 2026Article
- Evaluation of some photosensitizers against the cotton leaf worm, Spodoptera littoralis (Lepidoptera: Noctuidae), in relation to spectral and thermal reflectance.Scientific reports · 2024Article
- Photoinactivation of Multidrug-ResistantACS applied bio materials · 2024Article
- Antimicrobial Photodynamic Inactivation: An Alternative for Group BAntioxidants (Basel, Switzerland) · 2023Article
- Effective Biofilm Eradication on Orthopedic Implants with Methylene Blue Based Antimicrobial Photodynamic Therapy In Vitro.Antibiotics (Basel, Switzerland) · 2023Article
- Gallium Mesoporphyrin IX-Mediated Photodestruction: A Pharmacological Trojan Horse Strategy To Eliminate Multidrug-ResistantMolecular pharmaceutics · 2022Article
- Factors Determining the Susceptibility of Bacteria to Antibacterial Photodynamic Inactivation.Frontiers in medicine · 2021Review
- Photodynamic Inactivation of Methicillin-ResistantMolecules (Basel, Switzerland) · 2020Article
- Synthesis and In Vitro Photodynamic Activity of Cationic Boron Dipyrromethene-Based Photosensitizers against Methicillin-ResistantBiomedicines · 2020Article
- Evaluation of Antibacterial and Cytotoxicity Properties of Silver Nanowires and Their Composites with Carbon Nanotubes for Biomedical Applications.International journal of molecular sciences · 2020Article
- Effective Photodynamic Inactivation of 26Antibiotics (Basel, Switzerland) · 2020Article
- Application of Porphyrins in Antibacterial Photodynamic Therapy.Molecules (Basel, Switzerland) · 2019Review
- Photodynamic antimicrobial activity of new porphyrin derivatives against methicillin resistant Staphylococcus aureus.Journal of microbiology (Seoul, Korea) · 2018Article
- Article
- Antimicrobial Photodynamic Therapy to Control Clinically Relevant Biofilm Infections.Frontiers in microbiology · 2018Review
- Blue light treatment of Pseudomonas aeruginosa: Strong bactericidal activity, synergism with antibiotics and inactivation of virulence factors.Virulence · 2017Article
- Can microbial cells develop resistance to oxidative stress in antimicrobial photodynamic inactivation?Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2017Review
- Photodynamic antimicrobial chemotherapy with the novel amino acid-porphyrin conjugate 4I: In vitro and in vivo studies.PloS one · 2017Article
- Comments on "Biofilms of Candida albicans serotypes A and B differ in their sensitivity to photodynamic therapy".Lasers in medical science · 2015Article
- Article
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe current study was aimed at the investigation of differences in response to photoinactivation between methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive S. aureus (MSSA) isolates. Moreover, we aimed to elucidate if the observed variation resulted from antimicrobial resistance mechanisms and strains' susceptibility to antibiotic therapy. BACKGROUND DATA: Because of the emergence of multidrug resistance, the development of alternative antimicrobial strategies seems to be required. The concept of photodynamic inactivation (PDI) involves cell exposure to appropriate wavelength light that leads to the excitation of photosensitizer molecules, resulting in the production of reactive oxygen species responsible for cell inactivation and death. Recently, we have demonstrated a strain-dependent response of S. aureus to photoinactivation, and observed elevated resistance to PDI among MRSA strains. Nevertheless, the mechanism underlying this phenomenon remains unexplained.
methodsS. aureus response to protoporphyrin IX (PPIX)-mediated photoinactivation was studied for 424 MRSA/MSSA isolates. VITEK 2 Advanced Expert System was used to detect antimicrobial resistance mechanisms and strains' susceptibility to antibiotictherapy.
resultsData obtained demonstrated that MRSA are significantly more resistant to photoinactivation than MSSA strains; however, the difference observed did not result from antimicrobial susceptibility or resistance mechanisms. Furthermore, regardless of the strains' origin, a similar effectiveness of PDI could be achieved. Moreover, it was determined that the ability to form biofilms in vitro, and the presence of mec element, does not explain the observed differences between MRSA and MSSA strains.
conclusionsPDI could be highly effective against multidrug resistant pathogens as well as their naïve counterparts. Nevertheless, regardless of the antimicrobial resistance mechanism, the difference in response to PDI between MRSA and MSSA exists.
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