ArticleThe Journal of clinical endocrinology and metabolism2014
Multisystem dysregulation and bone strength: findings from the study of midlife in the United States.
Article in The Journal of clinical endocrinology and metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Stress-related multisystem dysregulation during adolescence predicts mental health symptoms in young adulthood.Psychological medicine · 2025Article
- Advancing the allostatic load model in military training research: from theory to application.Frontiers in physiology · 2025Review
- Depression predicts decreased lumbar bone mineral density: A scoping review of chronic psychological stress and spinal tissue pathology.Osteoarthritis and cartilage open · 2024Article
- Psychological Disorders Linked to Osteoporosis Diagnoses in a Population-Based Cohort Study of Middle and Older Age United States Adults.The Gerontologist · 2024Article
- The gender and age perspectives of allostatic load.Frontiers in medicine · 2024Review
- Conceptual and Analytical Overlap Between Allostatic Load and Systemic Biological Aging Measures: Analyses From the National Survey of Midlife Development in the United States.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Social stratification and allostatic load: shapes of health differences in the MIDUS study in the United States.Journal of biosocial science · 2019Article
- Vagally-mediated heart rate variability and indices of well-being: Results of a nationally representative study.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2017Article
- More than osteoporosis: age-specific issues in bone health.Current opinion in HIV and AIDS · 2016Review
- Allostatic Load and Personality: A 4-Year Longitudinal Study.Psychosomatic medicine · 2016Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
contextAccumulated dysregulation across multiple physiological systems, or allostatic load (AL), has been proposed as the biological pathway from psychosocial adversity to poor health.
objectiveThe objective of the study was to examine whether AL, constructed using biomarkers and medication data from seven systems (sympathetic, parasympathetic, hypothalamic-pituitary-adrenal axis, cardiovascular regulation, inflammation, and lipid and glucose metabolism), is associated with lower bone strength in a national sample.
designThis was a cross-sectional study. SETTING AND
participantsSeven hundred three community-dwelling men and women from the Study of Midlife in the United States participated in the study. OUTCOME MEASURES: Bone mineral density (BMD) was measured in the femoral neck and lumbar spine. Femoral neck BMD was combined with bone size and body size to create composite indices of femoral neck strength relative to load in three failure modes: compression, bending, and impact.
resultsIn mixed-effects linear regression controlling for clustering within families and adjusted for age, gender, race/ethnicity, body mass index, menopausal transition stage, childhood socioeconomic status, adult finances, education level, and study center, each SD increment in AL score was associated with between 0.10 and 0.11 SD decrements in lumbar spine BMD and each of the three composite strength indices (all values of P < .05). Gender modified the association of AL only with femoral neck BMD; each SD increment in AL score was associated with 0.21 SD decrement in femoral neck BMD in men (P < .01) but not in women.
conclusionsAccumulation of dysregulation across systems was modestly associated with lower bone strength. This study adds to the accumulating evidence that multisystem dysregulation, or AL, predicts a variety of adverse health outcomes.
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