ArticleStem cell reports2014
Conserved two-step regulatory mechanism of human epithelial differentiation.
Article in Stem cell reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 16 citations in OpenAlex.
- Phytoestrogens and related microbial metabolites remodel aberrant prostate transcriptomic profiles generated upon exposure to oxidative stress.Molecular and cellular biochemistry · 2026Article
- Proteasome-Mediated Regulation of GATA2 Expression and Androgen Receptor Transcription in Benign Prostate Epithelial Cells.Biomedicines · 2022Article
- Single-cell transcriptomics identifies a distinct luminal progenitor cell type in distal prostate invagination tips.Nature genetics · 2020Article
- Effects of Inorganic Arsenic on Human Prostate Stem-Progenitor Cell Transformation, Autophagic Flux Blockade, and NRF2 Pathway Activation.Environmental health perspectives · 2020Article
- Identification of new octamer transcription factor 1-target genes upregulated in castration-resistant prostate cancer.Cancer science · 2019Article
- Epigenetic Control of Gene Expression in the Normal and Malignant Human Prostate: A Rapid Response Which Promotes Therapeutic Resistance.International journal of molecular sciences · 2019Review
- Single-Cell Analysis Identifies LY6D as a Marker Linking Castration-Resistant Prostate Luminal Cells to Prostate Progenitors and Cancer.Cell reports · 2018Article
- Inhibition of the glucocorticoid receptor results in an enhanced miR-99a/100-mediated radiation response in stem-like cells from human prostate cancers.Oncotarget · 2016Article
- Context dependent regulatory patterns of the androgen receptor and androgen receptor target genes.BMC cancer · 2016Article
- The many ways to make a luminal cell and a prostate cancer cell.Endocrine-related cancer · 2015Review
- Elucidating drivers of oral epithelial dysplasia formation and malignant transformation to cancer using RNAseq.Oncotarget · 2015Article
- Construction of therapeutically relevant human prostate epithelial fate map by utilising miRNA and mRNA microarray expression data.British journal of cancer · 2015Article
- Targeting phenotypic heterogeneity in benign prostatic hyperplasia.Differentiation; research in biological diversityReview
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human epithelia are organized in a hierarchical structure, where stem cells generate terminally differentiated cells via intermediate progenitors. This two-step differentiation process is conserved in all tissues, but it is not known whether a common gene set contributes to its regulation. Here, we show that retinoic acid (RA) regulates early human prostate epithelial differentiation by activating a tightly coexpressed set of 80 genes (e.g., TMPRSS2). Response kinetics suggested that some of these genes could be direct RA targets, whereas others are probably responding indirectly to RA stimulation. Comparative bioinformatic analyses of published tissue-specific microarrays and a large-scale transcriptomic data set revealed that these 80 genes are not only RA responsive but also significantly coexpressed in many human cell systems. The same gene set preferentially responds to androgens during terminal prostate epithelial differentiation, implying a cell-type-dependent interplay between RA and tissue-specific transcription factor-mediated signaling in regulating the two steps of epithelial differentiation.
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