ArticleStem cell reports2014
In vivo targeting of adult neural stem cells in the dentate gyrus by a split-cre approach.
Article in Stem cell reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Characteristics of quiescent adult neural stem cells induced by the bFGF/BMP4 combination or BMP4 aloneFrontiers in cellular neuroscience · 2024Article
- An intein-split transactivator for intersectional neural imaging and optogenetic manipulation.Nature communications · 2022Article
- Astrogenesis in the murine dentate gyrus is a life-long and dynamic process.The EMBO journal · 2022Article
- Astrocytes, Noradrenaline, α1-Adrenoreceptors, and Neuromodulation: Evidence and Unanswered Questions.Frontiers in cellular neuroscience · 2021Review
- Circadian glucocorticoid oscillations preserve a population of adult hippocampal neural stem cells in the aging brain.Molecular psychiatry · 2020Article
- Neurogenesis From Embryo to Adult - Lessons From Flies and Mice.Frontiers in cell and developmental biology · 2020Review
- Mitochondrial Complex I Function Is Essential for Neural Stem/Progenitor Cells Proliferation and Differentiation.Frontiers in neuroscience · 2019Article
- MicroRNAs Engage in Complex Circuits Regulating Adult Neurogenesis.Frontiers in neuroscience · 2018Review
- Long-Term Labeling of Hippocampal Neural Stem Cells by a Lentiviral Vector.Frontiers in molecular neuroscience · 2018Article
- Radial glial cells in the adult dentate gyrus: what are they and where do they come from?F1000Research · 2018Review
- The cell of origin dictates the temporal course of neurofibromatosis-1 (Nf1) low-grade glioma formation.Oncotarget · 2017Article
- Synergic Functions of miRNAs Determine Neuronal Fate of Adult Neural Stem Cells.Stem cell reports · 2017Article
- SNX15 Regulates Cell Surface Recycling of APP and Aβ Generation.Molecular neurobiology · 2016Article
- Transgenic mouse models for studying adult neurogenesis.Frontiers in biology · 2016Article
- Heterogeneity of Radial Glia-Like Cells in the Adult Hippocampus.Stem cells (Dayton, Ohio) · 2016Article
- Theory and Practice of Lineage Tracing.Stem cells (Dayton, Ohio) · 2015Review
- Transcription-Factor-Dependent Control of Adult Hippocampal Neurogenesis.Cold Spring Harbor perspectives in biology · 2015Review
- SPOT14-positive neural stem/progenitor cells in the hippocampus respond dynamically to neurogenic regulators.Stem cell reports · 2014Article
- Single-cell technologies sharpen up mammalian stem cell research.Nature cell biology · 2014Review
- The taxonomy of brain cancer stem cells: what's in a name?Oncoscience · 2014Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We describe the labeling of adult neural stem cells (aNSCs) in the mouse and human dentate gyrus (DG) by the combinatorial expression of glial fibrillary acidic protein (GFAP) and Prominin1, as revealed by immunohistochemistry. Split-Cre-based genetic fate mapping of these double-positive cells in the adult murine DG reveals their NSC identity, as they are self-renewing and contribute to neurogenesis over several months. Their progeny reacts to stimuli such as voluntary exercise with increased neurogenesis. Prominin1+/GFAP+ cells also exist in the adult human DG, the only region in the human brain for which adult neurogenesis has been consistently reported. Our data, together with previous evidence of such double-positive NSCs in the developing murine brain and in neurogenic regions of vertebrates with widespread neurogenesis, suggest that Prominin1- and GFAP-expressing cells are NSCs in a wide range of species in development and adulthood.
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