Evidence map›Paper›PMID 24527357›Full record

ReviewAdvances in wound care2013

Ultraviolet Radiation in Wound Care: Sterilization and Stimulation.

Asheesh Gupta, Pinar Avci, Tianhong Dai, Ying-Ying Huang, Michael R Hamblin

Abstract readReview
In one paragraph

Review in Advances in wound care, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
3.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 349 citations in OpenAlex.

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  13. Photo-Responsive Ascorbic Acid-Modified AgACS applied materials & interfaces · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Asheesh GuptaWellman Center for Photomedicine, Massachusetts General Hospital , Boston, Massachusetts. ; Department of Dermatology, Harvard Medical School , Boston, Massachusetts. ; Defense Institute of Physiology and Allied Sciences (DIPAS) , Delhi, India .
Pinar AvciWellman Center for Photomedicine, Massachusetts General Hospital , Boston, Massachusetts.
Tianhong DaiWellman Center for Photomedicine, Massachusetts General Hospital , Boston, Massachusetts. ; Department of Dermatology, Harvard Medical School , Boston, Massachusetts.
Ying-Ying HuangWellman Center for Photomedicine, Massachusetts General Hospital , Boston, Massachusetts. ; Department of Dermatology, Harvard Medical School , Boston, Massachusetts. ; Department of Pathology, Guangxi Medical University , Nanning, China .
Michael R HamblinWellman Center for Photomedicine, Massachusetts General Hospital , Boston, Massachusetts. ; Department of Dermatology, Harvard Medical School , Boston, Massachusetts. ; Harvard-MIT Division of Health Sciences and Technology , Cambridge, Massachusetts.
Massachusetts General Hospital · USGuangxi Medical University · CNHarvard University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

significanceWound care is an important area of medicine considering the increasing age of the population who may have diverse comorbidities. Light-based technology comprises a varied set of modalities of increasing relevance to wound care. While low-level laser (or light) therapy and photodynamic therapy both have wide applications in wound care, this review will concentrate on the use of ultraviolet (UV) radiation. RECENT ADVANCES: UVC (200-280 nm) is highly antimicrobial and can be directly applied to acute wound infections to kill pathogens without unacceptable damage to host tissue. UVC is already widely applied for sterilization of inanimate objects. UVB (280-315 nm) has been directly applied to the wounded tissue to stimulate wound healing, and has been widely used as extracorporeal UV radiation of blood to stimulate the immune system. UVA (315-400 nm) has distinct effects on cell signaling, but has not yet been widely applied to wound care. CRITICAL ISSUES: Penetration of UV light into tissue is limited and optical technology may be employed to extend this limit. UVC and UVB can damage DNA in host cells and this risk must be balanced against beneficial effects. Chronic exposure to UV can be carcinogenic and this must be considered in planning treatments. FUTURE DIRECTIONS: New high-technology UV sources, such as light-emitting diodes, lasers, and microwave-generated UV plasma are becoming available for biomedical applications. Further study of cellular signaling that occurs after UV exposure of tissue will allow the benefits in wound healing to be better defined.

Identifiers

PMID24527357
PMCPMC3797459
OpenAlexW2022119002

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.