ReviewAdvances in wound care2013
Axolotl as a Model to Study Scarless Wound Healing in Vertebrates: Role of the Transforming Growth Factor Beta Signaling Pathway.
Review in Advances in wound care, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Wound healing in Atlantic spiny dogfish sharks.Scientific reports · 2026Article
- Streptozotocin induced hyperglycemia in the axolotl.Developmental dynamics : an official publication of the American Association of Anatomists · 2026Article
- Exploring Larval Axolotl Brain Development: Insights Into Developmental and Functional Constraints.Evolution & development · 2026Article
- Approaching Scarless Wound Healing: From Passive Anti-Fibrotic to Proactive and Programmable Pro-Regenerative Strategies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Axolotl-derived decellularized skin ECM as a pro-regenerative scaffold for attenuating fibrotic wound healing.Materials today. Bio · 2025Article
- Extracellular vesicles derived from mesenchymal stem cells: the wine in Hebe's hands to treat skin aging.Precision clinical medicine · 2024Review
- Cellular Localization and Distribution of TGF-β1, GDNF and PDGF-BB in the Adult Primate Central Nervous System.Neurochemical research · 2023Article
- Modulating Cellular Responses to Mechanical Forces to Promote Wound Regeneration.Advances in wound care · 2022Review
- Reawakening GDNF's regenerative past in mice and humans.Regenerative therapy · 2022Article
- The Diverse Manifestations of Regeneration and Why We Need to Study Them.Cold Spring Harbor perspectives in biology · 2021Article
- Finding Solutions for Fibrosis: Understanding the Innate Mechanisms Used by Super-Regenerator Vertebrates to Combat Scarring.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Mammals fail to regenerate organs when wound contraction drives scar formation.NPJ Regenerative medicine · 2021Review
- The complexity of TGFβ/activin signaling in regeneration.Journal of cell communication and signaling · 2021Review
- Tissue Engineering of Oral Mucosa and Salivary Gland: Disease Modeling and Clinical Applications.Micromachines · 2020Review
- Operation spinal cord regeneration: Patterning information residing in extracellular matrix glycosaminoglycans.Brain and behavior · 2020Review
- Review
- Macrophage-associated wound healing contributes to African green monkey SIV pathogenesis control.Nature communications · 2019Article
- Experimentally induced metamorphosis in highly regenerative axolotl (ambystoma mexicanum) under constant diet restructures microbiota.Scientific reports · 2018Article
- Learning from regeneration research organisms: The circuitous road to scar free wound healing.Developmental biology · 2018Review
- ITRAQ-based quantitative proteomic analysis of Cynops orientalis limb regeneration.BMC genomics · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
significanceThe skin is our largest organ, with the primary role of protection against assaults from the outside world. It also suffers frequent damage, from minor scrapes to, more rarely, complete destruction such as in third-degree burns. It is therefore, by its nature, an organ that would benefit tremendously from being able to regenerate itself. RECENT ADVANCES: This review highlights the axolotl, a less well-known model organism capable of scarless wound healing and regeneration. Axolotls are salamanders with unsurpassed healing and regenerative capacities. Understanding how these animals can regenerate their tissues could help identify the pathways that need to be activated or inhibited in humans to improve wound healing. CRITICAL ISSUES: Presently, there are no therapies leading to skin regeneration or scarless wound healing. Various animal models have thus been developed for use in research, such as mice and pigs, to help us understand how wound healing could be improved or stimulated. However, these more common models cannot regenerate and, consequently, cannot direct us toward a solution to regenerate damaged tissues. Axolotls, on the other hand, can regenerate perfectly and therefore may offer avenues to identify molecular targets for therapeutic intervention. FUTURE DIRECTIONS: Identifying signaling pathways regulating tissue regeneration in vertebrate models is important. The use of animals such as axolotls, which hold the secret of full regeneration, will likely play a significant role in helping us achieve scarless wound healing for humans.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.