Evidence map›Paper›PMID 24527344›Full record

ReviewAdvances in wound care2013

Critical Role of Transforming Growth Factor Beta in Different Phases of Wound Healing.

Mohammadreza Pakyari, Ali Farrokhi, Mohsen Khosravi Maharlooei, Aziz Ghahary

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advances in wound care, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 261 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
261citing papers in PubMed, 3 pooled it
17.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

261 citing papers in PubMed, 3 syntheses or guidelines pooled it, 591 citations in OpenAlex.

  1. Pooled it
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  18. Macroscopic Markers of Dolphin Healing at Sea Linked to Immunity.Animals : an open access journal from MDPI · 2026
    Article
  19. Life (Basel, Switzerland) · 2026
    Article
  20. Article

201 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Mohammadreza PakyariDepartment of Surgery, University of British Columbia , Vancouver, Canada .
Ali FarrokhiDepartment of Surgery, University of British Columbia , Vancouver, Canada . ; Professional Fire Fighters' Burn & Wound Healing Research Laboratory, University of British Columbia , Vancouver, Canada .
Mohsen Khosravi MaharlooeiDepartment of Surgery, University of British Columbia , Vancouver, Canada . ; Professional Fire Fighters' Burn & Wound Healing Research Laboratory, University of British Columbia , Vancouver, Canada .
Aziz GhaharyDepartment of Surgery, University of British Columbia , Vancouver, Canada . ; Professional Fire Fighters' Burn & Wound Healing Research Laboratory, University of British Columbia , Vancouver, Canada .
University of British Columbia · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

significanceThis review highlights the critical role of transforming growth factor beta (TGF-β)1-3 within different phases of wound healing, in particular, late-stage wound healing. It is also very important to identify the TGF-β1-controlling factors involved in slowing down the healing process upon wound epithelialization. RECENT ADVANCES: TGF-β1, as a growth factor, is a known proponent of dermal fibrosis. Several strategies to modulate or regulate TGF's actions have been thoroughly investigated in an effort to create successful therapies. This study reviews current discourse regarding the many roles of TGF-β1 in wound healing by modulating infiltrated immune cells and the extracellular matrix. CRITICAL ISSUES: It is well established that TGF-β1 functions as a wound-healing promoting factor, and thereby if in excess it may lead to overhealing outcomes, such as hypertrophic scarring and keloid. Thus, the regulation of TGF-β1 in the later stages of the healing process remains as critical issue of which to better understand. FUTURE DIRECTIONS: One hypothesis is that cell communication is the key to regulate later stages of wound healing. To elucidate the role of keratinocyte/fibroblast cross talk in controlling the later stages of wound healing we need to: (1) identify those keratinocyte-released factors which would function as wound-healing stop signals, (2) evaluate the functionality of these factors in controlling the outcome of the healing process, and (3) formulate topical vehicles for these antifibrogenic factors to improve or even prevent the development of hypertrophic scarring and keloids as a result of deep trauma, burn injuries, and any type of surgical incision.

Identifiers

PMID24527344
PMCPMC3857353
OpenAlexW2061251554

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.