ReviewAdvances in wound care2013
Age-Related Tissue Stiffening: Cause and Effect.
Review in Advances in wound care, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 68 citations in OpenAlex.
- Matrix metalloproteinase-mediated degradation governs angioarchitecture within poly(ethylene Glycol) hydrogels.Acta biomaterialia · 2026Article
- Mapping structural aging across human tissues reveals tissue-specific trajectories and coordinated deterioration.Nature aging · 2026Article
- Optic Disc and Retinal Strain Due to Vertical Duction.Investigative ophthalmology & visual science · 2026Article
- Evidence That Cardiac Pulse Strains Retinal Vessels in and near the Optic Disc During Ocular Ductions.Bioengineering (Basel, Switzerland) · 2026Article
- Visual field progression in varying severities of treated patients with primary angle closure glaucoma.Scientific reports · 2026Article
- Age-mimicking hydrogel stiffness recapitulates the mechanical niche of the hippocampus to regulate neural stem cell senescence.Materials today. Bio · 2026Article
- Lymphatic pumping technique in mice alters blood parameters and metastatic melanoma in an age-dependent manner.Experimental biology and medicine (Maywood, N.J.) · 2026Article
- Targeting the Glutaminolysis Pathway in Glaucoma-Associated Fibrosis.International journal of molecular sciences · 2025Review
- Usefulness of Measuring Corneal Stiffness in Predicting the Reduction of Intraocular Pressure With Microhook Ab Interno Trabeculotomy.Translational vision science & technology · 2025Article
- Advancing Exposure Index in Radiology for Optimized Imaging, Accuracy, and Future Innovations.Cureus · 2025Review
- Aging and intraocular pressure homeostasis in mice.Aging cell · 2024Article
- Experimental validation for the interconversion between generalized Kelvin-Voigt and Maxwell models using human skin tissues.Journal of biomechanics · 2024Article
- Scanning Laser Ophthalmoscopy Demonstrates Disc and Peripapillary Strain During Horizontal Eye Rotation in Adults.American journal of ophthalmology · 2023Article
- Endothelial tissue remodeling induced by intraluminal pressure enhances paracellular solute transport.iScience · 2023Article
- Effects ofFoods (Basel, Switzerland) · 2023Article
- Aging Effects on Optic Nerve Neurodegeneration.International journal of molecular sciences · 2023Review
- The choroid-sclera interface: An ultrastructural study.Heliyon · 2022Article
- Impact of Aging on the Ovarian Extracellular Matrix and Derived 3D Scaffolds.Nanomaterials (Basel, Switzerland) · 2022Article
- A trio of biological rhythms and their relevance in rhythmic mechanical stimulation of cell cultures.Frontiers in psychology · 2022Article
- Effect of Protease Inhibitors in Healing of the Vaginal Wall.Scientific reports · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
significanceTissue elasticity is severely compromised in aging skin, lungs, and blood vessels. In the vascular and pulmonary systems, respectively, loss of mechanical function is linked to hypertension, which in turn is a risk factor for heart and renal failure, stroke, and aortic aneurysms, and to an increased risk of mortality as a result of acute lung infections. RECENT ADVANCES: Although cellular mechanisms were thought to play an important role in mediating tissue aging, the reason for the apparent sensitivity of elastic fibers to age-related degradation remained unclear. We have recently demonstrated that compared with type I collagen, a key component of the elastic fiber system, the cysteine-rich fibrillin microfibril is highly susceptible to direct UV exposure in a cell-free environment. We hypothesized therefore that, as a consequence of both their remarkable longevity and cysteine-rich composition, many elastic fiber-associated components will be susceptible to the accumulation of damage by both direct UV radiation and reactive oxygen species-mediated oxidation. CRITICAL ISSUES: Although elastic fiber remodeling is a common feature of aging dynamic tissues, the inaccessibility of most human tissues has hampered attempts to define the molecular causes. CLINICAL CARE RELEVANCE: Although, currently, the localized repair of damaged elastic fibers may be effected by the topical application of retinoids and some cosmetic products, future studies may extend the application of systemic transforming growth factor β antagonists, which can prevent cardiovascular remodeling in murine Marfan syndrome, to aging humans. Acellular mechanisms may be key mediators of elastic fiber remodeling and hence age-related tissue stiffening.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.