ReviewAdvances in wound care2012
The Beginning of the End: CXCR3 Signaling in Late-Stage Wound Healing.
Review in Advances in wound care, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Cellular and Molecular Mechanisms of Wound Repair: From Biology to Therapeutic Innovation.Cells · 2025Review
- CXCR3-activating peptide inhibits pulmonary fibrosis in a bleomycin mouse model.Respiratory research · 2025Article
- Age-Related Changes in Neuroinflammation and Epigenetic Regulation in Mouse Ischemic Stroke Model.Brain sciences · 2025Article
- Polyurethane/silk fibroin-based electrospun membranes for wound healing and skin substitute applications.Beilstein journal of nanotechnology · 2025Review
- Cu(II)-baicalein enhance paracrine effect and regenerative function of stem cells in patients with diabetes.Bioactive materials · 2024Article
- Resistance training rejuvenates aging skin by reducing circulating inflammatory factors and enhancing dermal extracellular matrices.Scientific reports · 2023Article
- Molecular Mechanisms for the Vicious Cycle between Insulin Resistance and the Inflammatory Response in Obesity.International journal of molecular sciences · 2023Review
- Platelet-Released Growth Factors Influence Wound Healing-Associated Genes in Human Keratinocytes and Ex Vivo Skin Explants.International journal of molecular sciences · 2022Article
- Evolution, Expression and Functional Analysis of CXCR3 in Neuronal and Cardiovascular Diseases: A Narrative Review.Frontiers in cell and developmental biology · 2022Review
- Article
- Potential therapeutic manipulations of the CXCR3 chemokine axis for the treatment of inflammatory fibrosing diseases.F1000Research · 2020Article
- T-cell positioning by chemokines in autoimmune skin diseases.Immunological reviews · 2019Review
- CCL2 and CXCL10 are associated with poor outcome after intracerebral hemorrhage.Annals of clinical and translational neurology · 2018Article
- Immune Regulation of Skin Wound Healing: Mechanisms and Novel Therapeutic Targets.Advances in wound care · 2018Review
- The Role of CXCR3 and Its Chemokine Ligands in Skin Disease and Cancer.Frontiers in medicine · 2018Review
- Chemokine Signaling during Midline Epithelial Seam Disintegration Facilitates Palatal Fusion.Frontiers in cell and developmental biology · 2017Article
- ZNF395 Is an Activator of a Subset of IFN-Stimulated Genes.Mediators of inflammation · 2017Article
- Molecular Mechanism Underlying Pathogenesis of Lewisite-Induced Cutaneous Blistering and Inflammation: Chemical Chaperones as Potential Novel Antidotes.The American journal of pathology · 2016Article
- CXCR3 in carcinoma progression.Histology and histopathology · 2015Review
- CXCR3 chemokine receptor enables local CD8(+) T cell migration for the destruction of virus-infected cells.Immunity · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPrior to 2009, research regarding the role of CXC receptor 3 (CXCR3) in cutaneous biology was primarily in the context of inflammatory reactions. Foundational research performed at that time demonstrated that, in addition to recruited inflammatory cells, cellular components of the skin, keratinocytes, fibroblasts, and endothelial cells, also express CXCR3 and are capable of expressing CXCR3 ligands, specifically CXC ligand 10 (CXCL10) and CXCL11. Surprisingly, THE PROBLEM: These findings demonstrate the role of CXCR3 signaling in the latter stages of wounding healing and opened a new avenue of investigation into the molecular and cellular mechanisms of coordinating the events of cutaneous tissue regeneration. BASIC SCIENCE ADVANCES: More recent investigation highlights the role of CXCR3 signaling in the dramatic vascular pruning events after the proliferative stage of wound healing and its importance in guiding remodeling of dermal collagen during cicatrix formation.
conclusionCXCR3 signaling plays a strong role in coordinating the actions of several cell types during cutaneous wound healing. The disruption of this signaling pathway results in delayed return to homeostasis and dystrophic scarring.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.