Evidence map›Paper›PMID 24527266›Full record

ArticleLight, science & applications2013

Laser patterning for the study of MSC cardiogenic differentiation at the single-cell level.

Zhen Ma, Qiuying Liu, Huaxiao Yang, Raymond B Runyan, Carol A Eisenberg, Meifeng Xu, Thomas K Borg, Roger Markwald, Yifei Wang, Bruce Z Gao

Open access · goldAbstract read
In one paragraph

Article in Light, science & applications, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Applications of Bioengineered 3D Tissue and Tumor Organoids in Drug Development and Precision Medicine: Current and Future.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2018
    Review
  7. Tissue Engineering Approaches in the Design of Healthy and PathologicalFrontiers in bioengineering and biotechnology · 2017
    Review
  8. Review
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Zhen MaDepartment of Bioengineering and COMSET, Clemson University, Clemson, SC 29634, USA ; Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA.
Qiuying LiuBiomedical R&D Center, Jinan University, Guangzhou, China.
Huaxiao YangDepartment of Bioengineering and COMSET, Clemson University, Clemson, SC 29634, USA.
Raymond B RunyanDepartment of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ 85724, USA.
Carol A EisenbergNew York Medical College/Westchester Medical Center Stem Cell Laboratory, New York Medical College, Valhalla, New York, USA.
Meifeng XuDepartment of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, Cincinnati, OH, USA.
Thomas K BorgDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC, USA.
Roger MarkwaldDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC, USA.
Yifei WangBiomedical R&D Center, Jinan University, Guangzhou, China.
Bruce Z GaoDepartment of Bioengineering and COMSET, Clemson University, Clemson, SC 29634, USA.
Clemson University · USJinan University · CNMedical University of South Carolina · USNew York Medical College · USUniversity of Arizona · USUniversity of Cincinnati Medical Center · US

Funding

UNDERSTANDING AND CONTROLLING TISSUE-SPECIFIC VASCULAR PATTERNINGP20RR021949 · NCRR · CLEMSON UNIVERSITY · PI PETKOV, GEORGI V · 2009 to 2011
$5.2M
MicroRNA as mediators of angiogenesis & ischemic myocardial repairR01HL114654 · NHLBI · UNIVERSITY OF CINCINNATI · PI ASHRAF, MUHAMMAD, XU, MEIFENG · 2012 to 2016
$2.5M
Wnt11 signaling in stem cell survival and cardiac regenerationR01HL105176 · NHLBI · UNIVERSITY OF CINCINNATI · PI ASHRAF, MUHAMMAD, JONES, WALTER KEITH · 2010 to 2014
$1.9M
Dynamic Interaction Between Cardiac Fibroblasts, Myocytes and the ECMR01HL085847 · NHLBI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI BORG, THOMAS K · 2008 to 2012
$1.8M
Differentiation of Bone-Marrow Stem Cells in a Laser Patterned Myocyte CocultureK25HL088262 · NHLBI · CLEMSON UNIVERSITY · PI GAO, BRUCE Z · 2007 to 2011
$715k
NCRR NIH HHS P20 RR021949NHLBI NIH HHS K25 HL088262NHLBI NIH HHS R01 HL085847NHLBI NIH HHS R01 HL105176NHLBI NIH HHS R01 HL114654
6 · The paper itself

Abstract

Mesenchymal stem cells (MSCs) have been cited as contributors to heart repair through cardiogenic differentiation and multiple cellular interactions, including the paracrine effect, cell fusion, and mechanical and electrical couplings. Due to heart-muscle complexity, progress in the development of knowledge concerning the role of MSCs in cardiac repair is heavily based on MSC-cardiomyocyte coculture. In conventional coculture systems, however, the

Indexed as

cardiogenic differentiationmesenchymal stem cellsmicroenvironmentoptical forcesingle-cell analysis

Identifiers

PMID24527266
PMCPMC3920285
OpenAlexW1982278613

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.