Evidence map›Paper›PMID 24527224›Full record

ArticleISRN cardiology2014

Doxapram hydrochloride aggravates adrenaline-induced arrhythmias accompanied by bidirectional ventricular tachycardia.

Shota Oikawa, Hiroko Nomura, Miki Nishio, Rina Nagata, Tadayoshi Hata

Registry-linked trialOpen access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ISRN cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07022704 (The Influence of Doxapram Administration on Diaphragmatic Excursion in Mechanically Ventilated Patients With Chronic Obstructive Pulmonary Disease Undergoing Spontaneous Breathing Trial), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07022704 recruitingnot on this mapstarted 2025, after this paper: background citation

The Influence of Doxapram Administration on Diaphragmatic Excursion in Mechanically Ventilated Patients With Chronic Obstructive Pulmonary Disease Undergoing Spontaneous Breathing Trial: a Prospective Observational Study

TypeobservationalSponsorCairo UniversityRan2025 to 2025Enrolled35ConditionsCOPD, Mechanical Ventilation, Weaning From Mechanical VentilationArmsDoxapram
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Oxidative stress as a mechanism of added sugar-induced cardiovascular disease.The International journal of angiology : official publication of the International College of Angiology, Inc · 2014
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Shota OikawaDivision of Clinical Pathophysiology, Graduate School of Health Sciences, Fujita Health University, 1-98 Dengakugakubo Kutsukake, Toyoake, Japan.
Hiroko NomuraDivision of Pharmacology, Graduate School of Health Sciences, Fujita Health University, Japan.
Miki NishioDivision of Clinical Pathophysiology, Graduate School of Health Sciences, Fujita Health University, 1-98 Dengakugakubo Kutsukake, Toyoake, Japan.
Rina NagataDivision of Clinical Pathophysiology, Graduate School of Health Sciences, Fujita Health University, 1-98 Dengakugakubo Kutsukake, Toyoake, Japan.
Tadayoshi HataDivision of Clinical Pathophysiology, Graduate School of Health Sciences, Fujita Health University, 1-98 Dengakugakubo Kutsukake, Toyoake, Japan.
Fujita Health University Hospital · JPFujita Health University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives. Doxapram hydrochloride is a respiratory stimulant that has an inhibitory effect on myocardial IK1 potassium channels and is thought to increase membrane instability and excitability in myocardial cells. We examined the arrhythmogenic effects of doxapram hydrochloride in a rat model of halothane adrenaline-induced arrhythmia. Methods. Thirteen female Wistar rats (12-14 weeks old) were used in the study. Animals were anesthetized with inhalation of halothane to permit observation of the effects of doxapram hydrochloride on halothane adrenaline-induced arrhythmia. Time-dependent changes in ECG repolarization characteristics (QT, QTc, JTp, JT, and Tp-e intervals) were studied. Results. Doxapram hydrochloride itself did not induce arrhythmia but did induce bidirectional ventricular tachycardia after addition of adrenaline. Conclusion. Drug-induced impairment of intracellular Ca(2+) regulation caused BVT in the absence of genetic abnormalities in proteins in the sarcoplasmic reticulum.

Identifiers

PMID24527224
PMCPMC3912761
OpenAlexW2093428330

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.