ArticleSaudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society2014
Recent developments on dry eye disease treatment compounds.
Article in Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed, 50 citations in OpenAlex.
- A randomized study of the efficacy and safety of 0.1% cyclosporine A cationic emulsion in treatment of moderate to severe dry eye.European journal of ophthalmology · 2017Trial
- Assessing Tear Secretory Response in Health and Disease Using a Novel i-Onion Device.Eye & contact lens · 2025Article
- Review
- The Anti-Inflammatory Effect of Multi-Wavelength Light-Emitting Diode Irradiation Attenuates Dry Eye Symptoms in a Scopolamine-Induced Mouse Model of Dry Eye.International journal of molecular sciences · 2023Article
- Protective effect of Tisochrysis lutea on dry eye syndrome via NF-κB inhibition.Scientific reports · 2022Article
- Systemic Treatment of Immune-Mediated Keratoconjunctivitis Sicca with Allogeneic Stem Cells Improves the Schirmer Tear Test Score in a Canine Spontaneous Model of Disease.Journal of clinical medicine · 2021Article
- Effects of Eye Drops Containing Hyaluronic Acid-Nimesulide Conjugates in a Benzalkonium Chloride-Induced Experimental Dry Eye Rabbit Model.Pharmaceutics · 2021Article
- Inflammation in Dry Eye Syndrome: Identification and Targeting of Oxylipin-Mediated Mechanisms.Biomedicines · 2020Article
- Assessment of the tear film in normal eye subjects after consumption of a single dose of hot peppermint drink.Clinical optometry · 2019Article
- Subconjunctival dendrimer-drug therapy for the treatment of dry eye in a rabbit model of induced autoimmune dacryoadenitis.The ocular surface · 2018Article
- Effect of 5-Oxo-2-Pyrrolidinecarboxylic Acid (PCA) as a New Topically Applied Agent for Dry Eye Syndrome Treatment.Pharmaceutics · 2018Article
- Useful In Vitro Techniques to Evaluate the Mucoadhesive Properties of Hyaluronic Acid-Based Ocular Delivery Systems.Pharmaceutics · 2018Article
- Pathological Analysis of Ocular Lesions in a Murine Model of Sjögren's Syndrome.International journal of molecular sciences · 2017Article
- Preclinical mouse model to monitor live Muc5b-producing conjunctival goblet cell density under pharmacological treatments.PloS one · 2017Article
- Clinical evaluation of a nutraceutical diet as an adjuvant to pharmacological treatment in dogs affected by Keratoconjunctivitis sicca.BMC veterinary research · 2016Article
- Dry Eye Syndrome in Patients with Diabetes Mellitus: Prevalence, Etiology, and Clinical Characteristics.Journal of ophthalmology · 2016Review
- Assessment of Tear Film Quality among Smokers Using Tear Ferning Patterns.Journal of ophthalmology · 2016Article
- In pursuit of objective dry eye screening clinical techniques.Eye and vision (London, England) · 2016Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dry eye syndrome is a common tears and ocular surface multifactorial disease, described by changes in the ocular surface epithelia related to reduced tears quantity and ocular surface sensitivity, leading to inflammatory reaction. Managing the eye inflammation proved helpful to patients with dry eye disease and current treatment is based on the use of topically applied artificial tear products/lubricants, tear retention management, stimulation of tear secretion and using anti-inflammatory drugs. In this article we revise the corresponding literature and patents assembling the new treatment approaches of novel and future pharmaceutical compounds destined for the dry eye disease treatment. The most frequent categories of compounds presented are secretagogues and anti-inflammatory drugs. These compounds are the research outcome of novel therapeutic strategies designed to reduce key inflammatory pathways and restore healthy tear film.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.