ArticleFolia microbiologica2014
Identification of Streptomyces coelicolor M145 genomic region involved in biosynthesis of teichulosonic acid-cell wall glycopolymer.
Article in Folia microbiologica, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Salt supplementation-induced metabolic reprogramming inmSystems · 2026Article
- The Phosin PptA Plays a Negative Role in the Regulation of Antibiotic Production inAntibiotics (Basel, Switzerland) · 2021Article
- Highly improved acarbose production of Actinomyces through the combination of ARTP and penicillin susceptible mutant screening.World journal of microbiology & biotechnology · 2017Article
- TheFrontiers in microbiology · 2017Article
- Polydiglycosylphosphate Transferase PdtA (SCO2578) of Streptomyces coelicolor A3(2) Is Crucial for Proper Sporulation and Apical Tip Extension under Stress Conditions.Applied and environmental microbiology · 2016Article
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Authors and funding
8 authors.
Funding
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Abstract
The cell wall of the model actinomycete Streptomyces coelicolor M145 has recently been shown to contain the novel glycopolymer teichulosonic acid. The major building block of this polymer is 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (Kdn), suggesting initial clues about the genetic control of biosynthesis of this cell wall component. Here, through genome mining and gene knockouts, we demonstrate that the sco4879-sco4882 genomic region of S. coelicolor M145 is necessary for biosynthesis of teichulosonic acid. Specifically, mutants carrying individual knockouts of sco4879, sco4880 and sco4881 genes do not produce Kdn-containing glycopolymer and instead accumulate the minor cell wall component poly(diglycosyl 1-phosphate). Our studies provide evidence that this region is at least partly responsible for biosynthesis of Kdn, whereas flanking genes might control the other steps of teichulosonic acid formation.
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