Evidence map›Paper›PMID 24526514›Full record

ArticleThe Journal of antimicrobial chemotherapy2014

Adjunctive management of central line-associated bloodstream infections with 70% ethanol-lock therapy.

David W Kubiak, Erin T Gilmore, Mary W Buckley, Robert Lynch, Francisco M Marty, Sophia Koo

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of antimicrobial chemotherapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Ethanol Lock for Prevention of CVC-Related Bloodstream Infection in Pediatric Patients: A Systematic Review and Meta-Analysis.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2023
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

David W KubiakBrigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA dwkubiak@partners.org.
Erin T GilmoreBrigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.
Mary W BuckleyBrigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.
Robert LynchBrigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.
Francisco M MartyBrigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA Harvard Medical School, 250 Longwood Avenue, Boston, MA 02115, USA.
Sophia KooBrigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA Harvard Medical School, 250 Longwood Avenue, Boston, MA 02115, USA.
Brigham and Women's Hospital · USDana-Farber Cancer Institute · USHarvard University · US

Funding

Breath Volatile Metabolites for the Diagnosis of Emerging Invasive Mold InfectionK23AI097225 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI KOO, SOPHIA · 2012 to 2016
$685k
NIAID NIH HHS AI097225NIAID NIH HHS K23 AI097225
6 · The paper itself

Abstract

objectivesEthanol is bactericidal against most pathogens implicated in central line-associated bloodstream infections (CLABSIs) and biofilms. Current Infectious Diseases Society of America guidelines cite insufficient evidence to support adjunctive ethanol-lock therapy (ELT) for central venous catheter (CVC) salvage in patients with CLABSI in combination with systemic antimicrobial treatment. We evaluated the safety and potential efficacy of 70% ELT for CLABSI at our institution after implementation of a hospital ELT protocol.

methodsWe collected data on all patients treated with adjunctive 70% ELT for catheter salvage from September 2009 to September 2011 and assessed clinical outcomes and adverse events associated with ELT.

resultsSixty-eight hospitalized patients received 70% ELT for CVC salvage: 45 (66%) met the criteria for CLABSI. Five (11%) had persistent or recurrent bacteraemia triggering CVC removal; 28 (62%) preserved their CVC long term. There were no documented adverse events associated with ELT. DISCUSSION: Adjunctive 70% ELT is an inexpensive, well-tolerated option for CVC salvage in patients with CLABSI and warrants further investigation.

Indexed as

AdultAgedAged, 80 and overAnti-Infective AgentsAnti-Infective Agents, LocalCatheterization, Central VenousCentral Venous CathetersCombined Modality TherapyEthanolFemaleHumansMaleMiddle AgedSepsisTreatment OutcomeYoung AdultAnti-Infective AgentsAnti-Infective Agents, LocalEthanolbiofilmscatheter-related infectionssalvage therapy

Identifiers

PMID24526514
PMCPMC4019330
OpenAlexW2147698030

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.