ArticleMedical oncology (Northwood, London, England)2014
Association analysis between the c.1804C>A genetic polymorphism of XRCC1 gene and risk of hepatocellular carcinoma in Chinese population.
Article in Medical oncology (Northwood, London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- XRCC1 Gene Polymorphism Increases the Risk of Hepatocellular Carcinoma in Egyptian Population.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- Interleukin-17A and interleukin-17F gene polymorphisms and hepatitis B virus-related hepatocellular carcinoma risk in a Chinese population.Medical oncology (Northwood, London, England) · 2015Article
- Genetic polymorphisms in hypoxia-inducible factor-1a gene and its association with HBV-related hepatocellular carcinoma in a Chinese population.Medical oncology (Northwood, London, England) · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatocellular carcinoma (HCC) is a common liver malignancy in the world. The X-ray repair cross-complementing group 1 gene (XRCC1) is one of the most important candidate genes for influencing HCC risk. The purpose of this study was to evaluate the association between genetic polymorphisms of XRCC1 and HCC risk. A total of 592 HCC patients and 594 healthy controls were recruited in this case-control study. The c.1804C>A genetic polymorphism of XRCC1 gene was genotyped by the created restriction site-polymerase chain reaction and DNA sequencing methods. Our data suggested that the c.1804C>A genetic polymorphism of XRCC1 gene was significantly associated with the increased risk of HCC in the homozygote comparison (AA vs. CC: odds ratio (OR) 1.92, 95% confidence interval (CI) 1.25-2.94, P=0.003), recessive model (AA vs. CA/CC: OR 1.93, 95% CI 1.28-2.92, P=0.002), and allele comparison (A vs. C: OR 1.20, 95% CI 1.00-1.42, P=0.045). The allele A and genotype AA might contribute to the susceptibility to HCC. Our findings support that c.1804C>A genetic polymorphism of XRCC1 gene plays a genetic influence on the susceptibility to HCC in the studied population.
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