ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2014
Neuroprotective effect of levetiracetam on hypoxic ischemic brain injury in neonatal rats.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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16 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Levetiracetam versus Phenobarbitone for Management of Neonatal Seizures: A Systematic Review and Meta-analysis.Indian journal of pediatrics · 2025Pooled it
- Exploring how levetiracetam mitigates toxicity and ameliorates memory impairment.Frontiers in pharmacology · 2025Review
- A single exposure to brivaracetam or perampanel does not cause cell death in neonatal rats.Frontiers in pediatrics · 2024Article
- Neuroprotective therapies in the NICU in term infants: present and future.Pediatric research · 2023Review
- Retrospective Evaluation of First-line Levetiracetam use for Neonatal Seizures after Congenital Heart Defect repair with or without Extracorporeal Membrane Oxygenation.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2022Article
- Levetiracetam and N-Cadherin Antibody Alleviate Brain Pathology Without Reducing Early Epilepsy Development After Focal Non-convulsive Status Epilepticus in Rats.Frontiers in neurology · 2021Article
- Neuroprotective Effects of Lacosamide and Memantine on Hyperoxic Brain Injury in Rats.Neurochemical research · 2020Article
- LncRNA MIAT overexpression reduced neuron apoptosis in a neonatal rat model of hypoxic-ischemic injury through miR-211/GDNF.Cell cycle (Georgetown, Tex.) · 2019Article
- Current Overview of Neonatal Convulsions.Sisli Etfal Hastanesi tip bulteni · 2019Review
- Acute symptomatic seizures in term neonates: Etiologies and treatments.Seminars in fetal & neonatal medicine · 2018Review
- Does Levetiracetam Administration Prevent Cardiac Damage in Adulthood Rats Following Neonatal Hypoxia/Ischemia-Induced Brain Injury?Medicina (Kaunas, Lithuania) · 2018Article
- Comparative Effectiveness of Levetiracetam vs Phenobarbital for Infantile Epilepsy.JAMA pediatrics · 2018Observational
- Neuroprotection as a Potential Therapeutic Perspective in Neurodegenerative Diseases: Focus on Antiepileptic Drugs.Neurochemical research · 2016Review
- Response of levetiracetam in neonatal seizures.World journal of clinical pediatrics · 2015Article
- Article
- Increased apoptosis, tumor necrosis factor-α, and DNA damage attenuated by 3',4'-dihydroxyflavonol in rats with brain İschemia-reperfusion.Indian journal of pharmacologyArticle
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeHypoxic-ischemic brain injury that occurs in the perinatal period is one of the leading causes of mental retardation, visual and auditory impairment, motor defects, epilepsy, cerebral palsy, and death in neonates. The severity of apoptosis that develops after ischemic hypoxia and reperfusion is an indication of brain injury. Thus, it may be possible to prevent or reduce injury with treatments that can be given before the reperfusion period following hypoxia and ischemia. Levetiracetam is a new-generation antiepileptic drug that has begun to be used in the treatment of epilepsy.
methodsThe present study investigated the effects of levetiracetam on neuronal apoptosis with histopathological and biochemical tests in the early period and behavioral experiments in the late period.
resultsThis study showed histopathologically that levetiracetam reduces the number of apoptotic neurons and has a neuroprotective effect in a neonatal rat model of hypoxic-ischemic brain injury in the early period. On the other hand, we demonstrated that levetiracetam dose dependently improves behavioral performance in the late period.
conclusionsBased on these results, we believe that one mechanism of levetiracetam's neuroprotective effects is due to increases in glutathione peroxidase and superoxide dismutase enzyme levels. To the best of our knowledge, this study is the first to show the neuroprotective effects of levetiracetam in a neonatal rat model of hypoxic-ischemic brain injury using histopathological, biochemical, and late-period behavioral experiments within the same experimental group.
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