Evidence map›Paper›PMID 24526336›Full record

ArticleJournal of autism and developmental disorders2014

Quantitative linkage for autism spectrum disorders symptoms in attention-deficit/hyperactivity disorder: significant locus on chromosome 7q11.

Judith S Nijmeijer, Alejandro Arias-Vásquez, Nanda N J Rommelse, Marieke E Altink, Cathelijne J M Buschgens, Ellen A Fliers, Barbara Franke, Ruud B Minderaa, Joseph A Sergeant, Jan K Buitelaar and 2 more

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In one paragraph

Article in Journal of autism and developmental disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 1 country.

Judith S NijmeijerDepartment of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands, j.nijmeijer@accare.nl.
Alejandro Arias-Vásquez
Nanda N J Rommelse
Marieke E Altink
Cathelijne J M Buschgens
Ellen A Fliers
Barbara Franke
Ruud B Minderaa
Joseph A Sergeant
Jan K Buitelaar
Pieter J Hoekstra
Catharina A Hartman
Radboud University Nijmegen · NLUniversity Medical Center Groningen · NLKarakter · NLParnassia Groep · NLRadboud University Medical Center · NLUniversity of Groningen · NLVrije Universiteit Amsterdam · NL

Funding

International Multi-Center ADHD Genetics ProjectR01MH062873 · NIMH · UPSTATE MEDICAL UNIVERSITY · PI FARAONE, STEPHEN V · 2002 to 2007
$7.2M
Analysis of an ADHD Whole Genome Association ScanR01MH081803 · NIMH · UPSTATE MEDICAL UNIVERSITY · PI FARAONE, STEPHEN V · 2007 to 2007
$157k
NIMH NIH HHS R01MH081803NIMH NIH HHS R01MH62873
6 · The paper itself

Abstract

We studied 261 ADHD probands and 354 of their siblings to assess quantitative trait loci associated with autism spectrum disorder symptoms (as measured by the Children's Social Behavior Questionnaire (CSBQ)) using a genome-wide linkage approach, followed by locus-wide association analysis. A genome-wide significant locus for the CSBQ subscale addressing social interaction was found on chromosome 7q11, with suggestive signals supporting this locus on three other CSBQ subscales. We identified two other suggestive loci for the CSBQ total scale and individual subscales on chromosomes 4q35 and 7p12. Fine-mapping the significantly linked locus resulted in interesting candidate genes, although their association was not significant after permutation testing.

Indexed as

Genetic LinkageAttentionAttention Deficit Disorder with HyperactivityChildChild Development Disorders, PervasiveChromosome MappingChromosomes, Human, Pair 7FemaleHumansMaleSurveys and Questionnaires

Identifiers

PMID24526336
OpenAlexW2089300239

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.