Trial reportEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2014
Do analgesics improve functioning in patients with chronic low back pain? An explorative triple-blinded RCT.
Trial report in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02146482 (Evaluating Change in Back Pain From Access to a Sit-stand Workstation), which is not on this map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluating Change in Back Pain From Access to a Sit-stand Workstation
Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Paracetamol Combination Therapy for Back Pain and Osteoarthritis: A Systematic Review and Meta-Analyses.Drugs · 2024Pooled it
- Predictors of success of pharmacological management in patients with chronic lower back pain: systematic review.Journal of orthopaedic surgery and research · 2024Pooled it
- Paracetamol for low back pain.The Cochrane database of systematic reviews · 2016Pooled it
- Pharmacological management of chronic low back pain in older patients: a randomized controlled trial of the effect of pregabalin and opioid administration.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2015Trial
- Effectiveness of strategies for implementing guideline-concordant care in low back pain: a systematic review and meta-analysis of randomised controlled trials.EClinicalMedicine · 2025Article
- Context is Complex: Challenges and opportunities addressing contextual factors in manual therapy mechanisms research.International journal of osteopathic medicine : IJOM · 2025Article
- Effectiveness of strategies for implementing guideline-concordant care in low back pain: a systematic review and meta-analysis of randomised controlled trials.EClinicalMedicine · 2024Article
- Fibromyalgia pain management effectiveness from the patient perspective: a qualitative evidence synthesis.Disability and rehabilitation · 2024Review
- Impact of Prescription Medicines on Work-Related Outcomes in Workers with Musculoskeletal Disorders or Injuries: A Systematic Scoping Review.Journal of occupational rehabilitation · 2024Article
- Opioid Prescription Clusters Associated With Early or Unplanned Military Separation.Military medicine · 2024Article
- Association between Pain, Catastrophic Thinking, and Health-related Quality of Life in Patients with Hand Fractures.Progress in rehabilitation medicine · 2023Article
- An Updated Overview of Low Back Pain Management.Asian spine journal · 2022Article
- Impact of Work-Related Chronic Low Back Pain on Functional Performance and Physical Capabilities in Women and Men: A Sex-Wise Comparative Study.BioMed research international · 2022Article
- Pain catastrophizing and mental health phenotypes in adults with refractory chronic pain: A latent class analysis.Journal of psychiatric research · 2022Review
- Measuring Pain Catastrophizing and Pain-Related Self-Efficacy: Expert Panels, Focus Groups, and Cognitive Interviews.The patient · 2018Article
- Alternatives to Opioids in the Pharmacologic Management of Chronic Pain Syndromes: A Narrative Review of Randomized, Controlled, and Blinded Clinical Trials.Anesthesia and analgesia · 2017Review
- Impact of patient information leaflets on pain medication intake behavior: a pilot study.Pain reports · 2017Article
- An Updated Overview of Low Back Pain Management in Primary Care.Asian spine journal · 2017Review
- The Role of Psychosocial Processes in the Development and Maintenance of Chronic Pain.The journal of pain · 2016Review
- Patient phenotyping in clinical trials of chronic pain treatments: IMMPACT recommendations.Pain · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTREATMENT of patients with chronic low back pain (CLBP) aims to reduce disability, improve functional capacity, and participation. Time contingent prescription of analgesics is a treatment modality in CLBP. The impact of analgesics on functional capacity is unknown. Aim of the study was to explore the effect of analgesics on functioning measured by functional capacity evaluation, and self-reported disability in patients with CLBP.
methodsExplorative Randomized Placebo-Controlled Clinical Trial was performed in an outpatient pain rehabilitation setting on patients waiting for rehabilitation. Included patients had low back pain lasting >3 months, visual analogue scale worst pain ≥4.0 cm, and age >18 years. Outcome measures before (T0) and after treatment (T1): functional capacity, pain intensity, Roland Morris Disability Questionnaire. T1: global perceived pain relief. Patient characteristics and psychological questionnaires were assessed. Fifty patients were included in this study and were randomly assigned to 2 weeks treatment or placebo. TREATMENT: acetaminophen/tramadol 325 mg/37.5 mg per capsule. Dose: maximum acetaminophen 1,950 mg and tramadol 225 mg per day; treatment and placebo titrated identically. Compliance and side-effects were monitored. TREATMENT effects between groups over time were compared.
resultsOne patient (treatment group) was lost to follow-up. Forty-nine patients remained in the study. TREATMENT effects in primary outcomes did not differ significantly between groups. A subgroup of 10 (42%) patients (treatment group) reported global pain relief (responders) who reduced self-reported disability (p < 0.05). Responders had significantly lower catastrophizing scores.
conclusionOverall treatment effects were small and non-significant. A subgroup, however, reported improved functioning as a result of treatment. Responders had lower catastrophizing scores.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.