ArticleInternational journal of molecular sciences2014
Antioxidant and protective mechanisms against hypoxia and hypoglycaemia in cortical neurons in vitro.
Article in International journal of molecular sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- Asiatic acid inOpen veterinary journal · 2023Article
- Functional characterisation of the amyotrophic lateral sclerosis risk locus GPX3/TNIP1.Genome medicine · 2022Article
- A neuroglobin-based high-affinity ligand trap reverses carbon monoxide-induced mitochondrial poisoning.The Journal of biological chemistry · 2020Article
- Mitochondrial Dysfunction and Changes in High-Energy Compounds in Different Cellular Models Associated to Hypoxia: Implication to Schizophrenia.Scientific reports · 2019Article
- Long noncoding RNA glutathione peroxidase 3-antisense inhibits lens epithelial cell apoptosis by upregulating glutathione peroxidase 3 expression in age-related cataract.Molecular vision · 2019Article
- Differential regulation of pro- and antiapoptotic proteins in fish adipocytes during hypoxic conditions.Fish physiology and biochemistry · 2016Article
- Protective effects of vascular endothelial growth factor in cultured brain endothelial cells against hypoglycemia.Metabolic brain disease · 2015Article
- Article
- Females transplanted with ovaries subjected to hypoxic preconditioning show impair of ovarian function.Journal of ovarian research · 2014Article
- A paradoxical chemoresistance and tumor suppressive role of antioxidant in solid cancer cells: a strange case of Dr. Jekyll and Mr. Hyde.BioMed research international · 2014Review
- Associations between arterial oxygenation and oxidative stress markers in serum and bronchoalveolar lavage fluid of patients with severe brain injury.Frontiers in neurologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the present work, we have studied whether cell death could be induced in cortical neurons from rats subjected to different period of O2 deprivation and low glucose (ODLG). This "in vitro" model is designed to emulate the penumbra area under ischemia. In these conditions, cortical neurons displayed loss of mitochondrial respiratory ability however, nor necrosis neither apoptosis occurred despite ROS production. The absence of cellular death could be a consequence of increased antioxidant responses such as superoxide dismutase-1 (SOD1) and GPX3. In addition, the levels of reduced glutathione were augmented and HIF-1/3α overexpressed. After long periods of ODLG (12-24 h) cortical neurons showed cellular and mitochondrial membrane alterations and did not recuperate cellular viability during reperfusion. This could mean that therapies directed toward prevention of cellular and mitochondrial membrane imbalance or cell death through mechanisms other than necrosis or apoptosis, like authophagy, may be a way to prevent ODLG damage.
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Registered trials
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