Trial reportPediatric nephrology (Berlin, Germany)2014
Regional citrate anticoagulation for pediatric CRRT using integrated citrate software and physiological sodium concentration solutions.
Trial report in Pediatric nephrology (Berlin, Germany), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 29 citations in OpenAlex.
- Effects of different continuous renal replacement therapy patterns on ionized calcium in patients with citrate anticoagulants using calcium-containing replacement solutions: a study protocol.Annals of medicine · 2025Article
- Regional citrate anticoagulation algorithm and management protocol aimed at ensuring blood calcium stability: a prospective single-arm study.Clinical kidney journal · 2025Article
- Citrate anticoagulation and systemic heparin anticoagulation during continuous renal replacement therapy among critically-ill children.Pediatric research · 2024Article
- Evaluation of the efficacy and associated complications of regional citrate anticoagulation in neonates: experience from a fourth level neonatal intensive care unit.European journal of pediatrics · 2023Article
- A simplified protocol of regional citrate anticoagulation with phosphate-containing solutions in infants and children treated with continuous kidney replacement therapy.Pediatric nephrology (Berlin, Germany) · 2023Article
- Regional citrate anticoagulation for continuous renal replacement therapy in newborns.Frontiers in pediatrics · 2023Article
- Anticoagulation in patients with acute kidney injury undergoing kidney replacement therapy.Pediatric nephrology (Berlin, Germany) · 2022Article
- Effect of adult COVID-19 surge on the provision of kidney replacement therapy in children.Pediatric nephrology (Berlin, Germany) · 2020Article
- Regional citrate anticoagulation with a substitute containing calcium for continuous hemofiltration in children.Medicine · 2019Observational
- Regional citrate anticoagulation for continuous renal replacement therapy in children.Pediatric nephrology (Berlin, Germany) · 2017Observational
- Regional citrate anticoagulation for continuous renal replacement therapy in pediatric patients with liver failure.PloS one · 2017Article
- Regional citrate anticoagulation for renal replacement therapies in patients with acute kidney injury: a position statement of the Work Group "Renal Replacement Therapies in Critically Ill Patients" of the Italian Society of Nephrology.Journal of nephrology · 2015Review
- Regional citrate anticoagulation for RRTs in critically ill patients with AKI.Clinical journal of the American Society of Nephrology : CJASN · 2014Review
- Regional citrate anticoagulation for pediatric CRRT using integrated citrate software.Pediatric nephrology (Berlin, Germany) · 2014Article
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7 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundIn continuous renal replacement therapy (CRRT), regional citrate anticoagulation offers an attractive alternative to heparinization, especially for children with a high bleeding risk.
methodsWe report on a new management approach to CRRT using integrated citrate software and physiological sodium concentration solutions. Convective filtration was performed with pre-filter citrate anticoagulation using an 18 mmol/L citrate solution and a post-filter replacement fluid. The citrate flow rate was automatically adjusted to the blood flow rate by means of integrated citrate software. Similarly, calcium was automatically infused into children to maintain their blood calcium levels within normal range.
resultsEleven CRRT sessions were performed (330 h) in seven critically ill children aged 3-15 years (extreme values 15-66 kg). Disease categories included sepsis with multiorgan dysfunction (n = 2) and hemolytic uremic syndrome (n = 5). Median effluent dose was 2.1 (extreme values 1.7-3.3) L/h/1.73 m2. No session had to be stopped because of metabolic complications. Calcium levels, both in the circuits and in the circulating blood of the children, remained stable and secure.
conclusionsRegional citrate anticoagulation can be used in children with a body weight of >15 kg using integrated citrate software and commercially available solutions with physiological sodium concentrations in a safe, effective and convenient procedure.
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