Trial reportStroke2014
Serial Alberta Stroke Program early CT score from baseline to 24 hours in Solitaire Flow Restoration with the Intention for Thrombectomy study: a novel surrogate end point for revascularization in acute stroke.
Trial report in Stroke, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01054560 (SOLITAIRE™ FR With the Intention For Thrombectomy), which is not on this map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
SOLITAIRE™ FR With the Intention For Thrombectomy (SWIFT) Study
Who cites it
22 citing papers in PubMed.
- Using radiological brain health to predict recurrence after ischemic stroke and transient ischemic attack: A population-based study.Neurology open access · 2026Article
- ASPECTS evolution after endovascular successful reperfusion in the early and extended time window.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2026Article
- Article
- Improving the diagnosis of acute ischemic stroke on non-contrast CT using deep learning: a multicenter study.Insights into imaging · 2022Article
- Predictors of Early Neurological Improvement in Patients with Anterior Large Vessel Occlusion and Successful Reperfusion Following Endovascular Thrombectomy-Does CT Perfusion Imaging Matter?Clinical neuroradiology · 2022Article
- The Application of Computed Tomography Perfusion in the Alberta Stroke Program Early Computed Tomography Score for Endovascular Treatment of Acute Ischemic Stroke in the Anterior Circulation.International journal of general medicine · 2021Article
- Predictors of the pulsatility index in the middle cerebral artery of acute stroke patients.Scientific reports · 2020Article
- Application of FLAIR Vascular Hyperintensity-DWI Mismatch in Ischemic Stroke Depending on Semi-Quantitative DWI-Alberta Stroke Program Early CT Score.Frontiers in neurology · 2019Article
- Hyper-attenuating brain lesions on CT after ischemic stroke and thrombectomy are associated with final brain infarction.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2017Article
- Estimating the number of UK stroke patients eligible for endovascular thrombectomy.European stroke journal · 2017Article
- e-ASPECTS Correlates with and Is Predictive of Outcome after Mechanical Thrombectomy.AJNR. American journal of neuroradiology · 2017Article
- Imaging of Ischemic Stroke.Continuum (Minneapolis, Minn.) · 2016Review
- Early neurological stability predicts adverse outcome after acute ischemic stroke.International journal of stroke : official journal of the International Stroke Society · 2016Article
- Extending the Time Window for Endovascular and Pharmacological Reperfusion.Translational stroke research · 2016Review
- Immunohistochemical Analysis of Cerebral Thrombi Retrieved by Mechanical Thrombectomy from Patients with Acute Ischemic Stroke.International journal of molecular sciences · 2016Article
- Optimization of beam quality for photon-counting spectral computed tomography in head imaging: simulation study.Journal of medical imaging (Bellingham, Wash.) · 2015Article
- Googling Stroke ASPECTS to Determine Disability: Exploratory Analysis from VISTA-Acute Collaboration.PloS one · 2015Article
- DWI Lesion Patterns Predict Outcome in Stroke Patients with Thrombolysis.Cerebrovascular diseases (Basel, Switzerland) · 2015Article
- Article
- Impact of collaterals on successful revascularization in Solitaire FR with the intention for thrombectomy.Stroke · 2014Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
background and purposeThe Alberta Stroke Program Early CT Score (ASPECTS) on baseline imaging is an established predictor of acute ischemic stroke outcomes. We analyzed change on serial ASPECTS at baseline and 24-hour imaging in the Solitaire Flow Restoration with the Intention for Thrombectomy (SWIFT) study to determine prognostic value and to identify subgroups with extensive injury after intervention.
methodsASPECTS at baseline and 24 hours was independently scored in all anterior circulation SWIFT cases, blinded to all other trial data. ASPECTS at baseline, at 24 hours, and serial changes were analyzed with univariate and multivariate approaches.
resultsOne hundred thirty-nine patients (mean age, 67 [SD, 12] years; 52% women; median National Institutes of Health Stroke Scale, 18 [interquartile range, 8-28]) with complete data at both time points were studied. Multivariate analyses showed that higher 24-hour ASPECTS predicted good clinical outcome (day 90 modified Rankin Scale, 0-2; odds ratio, 1.67; P<0.001). Among patients with high baseline ASPECTS (8-10; n=109), dramatic infarct progression (decrease in ASPECTS ≥6 points at 24 hours) was noted in 31 of 109 (28%). Such serial ASPECTS change was predicted by higher baseline systolic blood pressure (P=0.019), higher baseline blood glucose (P=0.133), and failure to achieve Thrombolysis in Cerebral Infarction score of 2b/3 reperfusion (P<0.001), culminating in worse day 90 modified Rankin Scale outcomes (mean modified Rankin Scale, 4.4 versus 2.7; P<0.001).
conclusionsTwenty-four-hour ASPECTS provides better prognostic information compared with baseline ASPECTS. Predictors of dramatic infarct progression on ASPECTS are hyperglycemia, hypertension, and nonreperfusion. Serial ASPECTS change from baseline to 24 hours predicts clinical outcome, providing an early surrogate end point for thrombectomy trials. CLINICAL TRIAL REGISTRATION URL: http://www.clinicaltrials.gov. Unique identifier: NCT01054560.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.