ArticleNuclear medicine communications2014
Improving quantitative dosimetry in (177)Lu-DOTATATE SPECT by energy window-based scatter corrections.
Article in Nuclear medicine communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32 citing papers in PubMed.
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- Quantitative SPECT/CT: Technique and Clinical Applications.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026Review
- Lutetium-177-Prostate-Specific Membrane Antigen Radioligand Therapy: What Is the Value of Post-Therapeutic Imaging?Biomedicines · 2024Review
- Position dependence of recovery coefficients inEJNMMI physics · 2024Article
- Activity quantification and dosimetry in radiopharmaceutical therapy with reference toFrontiers in nuclear medicine · 2024Review
- Semi-automated segmentation methods of SSTR PET for dosimetry prediction in refractory meningioma patients treated by SSTR-targeted peptide receptor radionuclide therapy.European radiology · 2023Review
- Physics-Guided Deep Scatter Estimation by Weak Supervision for Quantitative SPECT.IEEE transactions on medical imaging · 2023Article
- Performance study of a 360° CZT camera for monitoringEJNMMI physics · 2023Article
- Specific Uptake in the Bone Marrow Causes High Absorbed Red Marrow Doses During [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023Article
- Towards accurateEJNMMI physics · 2023Article
- First experiences with dynamic renal [European journal of nuclear medicine and molecular imaging · 2022Article
- Reconstructed SPECT images ofScientific data · 2022Article
- [European journal of nuclear medicine and molecular imaging · 2022Article
- Evaluation of quantitative accuracy among different scatter corrections for quantitative bone SPECT/CT imaging.PloS one · 2022Article
- Optimization of SPECT/CT imaging protocols for quantitative and qualitativeEJNMMI physics · 2021Article
- The effect of calibration factors and recovery coefficients onEJNMMI physics · 2021Article
- Article
- Crosstalk Reduction Using a Dual Energy Window Scatter Correction in Compton Imaging.Sensors (Basel, Switzerland) · 2020Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
purposePatient-specific dosimetry of lutetium-177 ((177)Lu)-DOTATATE treatment in neuroendocrine tumours is important, because uptake differs across patients. Single photon emission computer tomography (SPECT)-based dosimetry requires a conversion factor between the obtained counts and the activity, which depends on the collimator type, the utilized energy windows and the applied scatter correction techniques. In this study, energy window subtraction-based scatter correction methods are compared experimentally and quantitatively. MATERIALS AND
methods(177)Lu SPECT images of a phantom with known activity concentration ratio between the uniform background and filled hollow spheres were acquired for three different collimators: low-energy high resolution (LEHR), low-energy general purpose (LEGP) and medium-energy general purpose (MEGP). Counts were collected in several energy windows, and scatter correction was performed by applying different methods such as effective scatter source estimation (ESSE), triple-energy and dual-energy window, double-photopeak window and downscatter correction. The intensity ratio between the spheres and the background was measured and corrected for the partial volume effect and used to compare the performance of the methods.
resultsLow-energy collimators combined with 208 keV energy windows give rise to artefacts. For the 113 keV energy window, large differences were observed in the ratios for the spheres. For MEGP collimators with the ESSE correction technique, the measured ratio was close to the real ratio, and the differences between spheres were small.
conclusionFor quantitative (177)Lu imaging MEGP collimators are advised. Both energy peaks can be utilized when the ESSE correction technique is applied. The difference between the calculated and the real ratio is less than 10% for both energy windows.
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