ArticleRNA biology2014
The emerging roles of eRNAs in transcriptional regulatory networks.
Article in RNA biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- The Mediator complex: co-transcriptional regulation and beyond.RNA biology · 2026Review
- Epigenetic profiling reveals key super-enhancer networks driving oncogenesis in HPV-positive HNSCC.iScience · 2025Article
- The Emerging Role of Super-enhancers as Therapeutic Targets in The Digestive System Tumors.International journal of biological sciences · 2023Review
- Enhancer occlusion transcripts regulate the activity of human enhancer domains via transcriptional interference: a computational perspective.Nucleic acids research · 2020Article
- Structure, Regulation, and Function of Linear and Circular Long Non-Coding RNAs.Frontiers in genetics · 2020Review
- Functions and Regulatory Mechanisms of lncRNAs in Skeletal Myogenesis, Muscle Disease and Meat Production.Cells · 2019Review
- Functional Conservation of a Developmental Switch in Mammals since the Jurassic Age.Molecular biology and evolution · 2019Article
- Long Noncoding RNAs: Emerging Players in Medulloblastoma.Frontiers in pediatrics · 2019Review
- Deficiency in the nuclear long noncoding RNAThe EMBO journal · 2018Article
- Roles of Enhancer RNAs in RANKL-induced Osteoclast Differentiation Identified by Genome-wide Cap-analysis of Gene Expression using CRISPR/Cas9.Scientific reports · 2018Article
- The Ever-Evolving Concept of the Gene: The Use of RNA/Protein Experimental Techniques to Understand Genome Functions.Frontiers in molecular biosciences · 2018Review
- Current Advances on the Important Roles of Enhancer RNAs in Gene Regulation and Cancer.BioMed research international · 2018Review
- Mutations in ACTRT1 and its enhancer RNA elements lead to aberrant activation of Hedgehog signaling in inherited and sporadic basal cell carcinomas.Nature medicine · 2017Article
- Article
- Chromatin remodeling effects on enhancer activity.Cellular and molecular life sciences : CMLS · 2016Review
- Non-coding RNAs in muscle differentiation and musculoskeletal disease.The Journal of clinical investigation · 2016Review
- Unraveling the mechanisms of chromatin fibril packaging.Nucleus (Austin, Tex.) · 2016Article
- MUNC, a long noncoding RNA that facilitates the function of MyoD in skeletal myogenesis.Molecular and cellular biology · 2015Article
- Inflammation-sensitive super enhancers form domains of coordinately regulated enhancer RNAs.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Genome-Wide Definition of Promoter and Enhancer Usage during Neural Induction of Human Embryonic Stem Cells.PloS one · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Following reports by ENCyclopedia Of DNA Elements (ENCODE; GENCODE) Consortium and others, it is now fairly evident that the majority (70-80%) of the mammalian genome has the potential to be transcribed into non-protein-coding RNAs (ncRNAs). Critical to our understanding of genetic processes is the mechanism by which ncRNAs exert their roles. Accordingly, ncRNAs are shown to regulate the expression of protein-coding loci (i.e., genes) at the transcriptional as well as post-transcriptional stages. We recently reported on a widespread transcription at the DNA enhancer elements in myogenic cells. In our study, we found certain enhancer RNAs (eRNAs) regulate chromatin accessibility of the transcriptional machinery at loci encoding master regulators of myogenesis (i.e., MyoD/MyoG), thus suggesting their significance and site-specific impact in cellular programming. Here, we examine recent discoveries pertinent to the proposed role(s) of eRNAs in regulating gene expression. We will highlight consistencies, discuss confounding observations, and consider a lack of critical information in a way to prioritize future objectives.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.