Evidence map›Paper›PMID 24525471›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2014

Reduced adherence to antiretroviral therapy among HIV-infected Tanzanians seeking cure from the Loliondo healer.

Nathan M Thielman, Jan Ostermann, Kathryn Whetten, Rachel Whetten, Dafrosa Itemba, Venance Maro, Brian Pence, Elizabeth Reddy, CHAT Research Team

Abstract read
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 35 citations in OpenAlex.

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  16. The ethics of talking about 'HIV cure'.BMC medical ethics · 2015
    Article
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  19. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Nathan M Thielman*Center for Health Policy and Inequalities Research; †Duke Global Health Institute, Duke University, Durham, NC; ‡Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, NC; §Tanzania Women's Research Foundation (TAWREF), Moshi, Tanzania; ‖Kilimanjaro Christian Medical Centre (KCMC), Moshi, Tanzania; and ¶Department of Community and Family Medicine, Duke University Medical Center, Durham, NC.
Jan Ostermann
Kathryn Whetten
Rachel Whetten
Dafrosa Itemba
Venance Maro
Brian Pence
Elizabeth Reddy
CHAT Research Team
Kilimanjaro Christian Medical Centre · TZDuke Medical Center · USDuke University Hospital · USTanzania Women Research Foundation · TZ

Funding

Social and Behavioral Sciences CoreP30AI064518 · NIAID · DUKE UNIVERSITY · PI Nwora Lance Okeke · 2005 to 2026
$50.5M
Duke CTSIKL2RR024127 · NCRR · DUKE UNIVERSITY · PI CALIFF, ROBERT M · 2006 to 2011
$3.9M
Coping With HIV/AIDS in TanzaniaR01MH078756 · NIMH · DUKE UNIVERSITY · PI WHETTEN, KATHRYN · 2007 to 2012
$2.9M
NCRR NIH HHS KL2 RR024127NCRR NIH HHS KL2-RR024127-04NIAID NIH HHS 5P30-AI064518-08NIAID NIH HHS P30 AI064518NIMH NIH HHS 5R01MH078756NIMH NIH HHS R01 MH078756
6 · The paper itself

Abstract

: The predictors for seeking alternative therapies for HIV-infection in sub-Saharan Africa are unknown. Among a prospective cohort of 442 HIV-infected patients in Moshi, Tanzania, 249 (56%) sought cure from a newly popularized religious healer in Loliondo (450 km away), and their adherence to antiretrovirals (ARVs) dropped precipitously (odds ratio = 0.20, 95% confidence interval: 0.09 to 0.44, P < 0.001) after the visit. Compared with those not attending Loliondo, attendees were more likely to have been diagnosed with HIV more remotely (3.8 vs. 3.0 years before, P < 0.001), have taken ARVs longer (3.4 vs. 2.5 years, P < 0.001), have higher median CD4 lymphocyte counts (429 vs. 354 cells/mm, P < 0.001), be wealthier (wealth index: 10.9 vs. 8.8, P = 0.034), and receive care at the private versus the public hospital (P = 0.012). In multivariable logistic regression, only years since the start of ARVs remained significant (odds ratio = 1.49, 95% confidence interval: 1.23 to 1.80). Treatment fatigue may play a role in the lure of alternative healers.

Indexed as

Antiretroviral Therapy, Highly ActiveDrug MonitoringAfricaAnti-Retroviral AgentsCD4 Lymphocyte CountFaith HealingHIV InfectionsHumansTanzaniaAnti-Retroviral Agents

Identifiers

PMID24525471
PMCPMC4006017
OpenAlexW2014040510

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.