Evidence map›Paper›PMID 24525452›Full record

ReviewGeneral and comparative endocrinology2014

Comparative endocrinology of leptin: assessing function in a phylogenetic context.

Richard L Londraville, Yazmin Macotela, Robert J Duff, Marietta R Easterling, Qin Liu, Erica J Crespi

Open access · greenAbstract readReview
In one paragraph

Review in General and comparative endocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 103 citations in OpenAlex.

  1. Trial
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  10. Leptin ameliorates the immunity, but not reproduction, trade-off with endurance in lizards.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2019
    Article
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  12. Review
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  20. Appetite-Controlling Endocrine Systems in Teleosts.Frontiers in endocrinology · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Richard L LondravilleDepartment of Biology and Program in Integrated Biosciences, University of Akron, Akron, OH, USA. Electronic address: londraville@uakron.edu.
Yazmin MacotelaInstituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro, Mexico.
Robert J DuffDepartment of Biology and Program in Integrated Biosciences, University of Akron, Akron, OH, USA.
Marietta R EasterlingSchool of Biological Sciences and Center for Reproductive Biology, Washington State University, Pullman, WA 99164, USA.
Qin LiuDepartment of Biology and Program in Integrated Biosciences, University of Akron, Akron, OH, USA.
Erica J CrespiSchool of Biological Sciences and Center for Reproductive Biology, Washington State University, Pullman, WA 99164, USA.
University of Akron · USWashington State University · USUniversidad Nacional Autónoma de México · MX

Funding

Characterization of leptin's effects in early developing and adult zebrafishR15DK079282 · NIDDK · UNIVERSITY OF AKRON · PI LONDRAVILLE, RICHARD LYLE · 2008 to 2012
$687k
LEPTIN STRUCTURE AND FUNCTION IN GREEN SUNFISHR15DK058113 · NIDDK · UNIVERSITY OF AKRON · PI LONDRAVILLE, RICHARD LYLE · 2000 to 2000
$135k
NICHD NIH HHS 1R15HD060009-01NIDDK NIH HHS 1R15DK079282-01A1NIDDK NIH HHS 2 R15 DK079282-02NIDDK NIH HHS R15 DK058113NIDDK NIH HHS R15 DK079282
6 · The paper itself

Abstract

As we approach the end of two decades of leptin research, the comparative biology of leptin is just beginning. We now have several leptin orthologs described from nearly every major clade among vertebrates, and are moving beyond gene descriptions to functional studies. Even at this early stage, it is clear that non-mammals display clear functional similarities and differences with their better-studied mammalian counterparts. This review assesses what we know about leptin function in mammals and non-mammals, and gives examples of how these data can inform leptin biology in humans.

Indexed as

Evolution, MolecularPhylogenyAnimalsEndocrinologyHumansLeptinPhysiology, ComparativeVertebratesLeptinAmphibiansFishImmunologyLeptinPhylogenyVertebrates

Identifiers

PMID24525452
PMCPMC4128956
OpenAlexW2037447100

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.