Evidence map›Paper›PMID 24525253›Full record

ArticleNutrition, metabolism, and cardiovascular diseases : NMCD2014

Effects of equol on gene expression in female cynomolgus monkey iliac arteries.

K Eyster, S Appt, A Chalpe, T Register, T Clarkson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrition, metabolism, and cardiovascular diseases : NMCD, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

K EysterDivision of Basic Biomedical Sciences, Sanford School of Medicine of the University of South Dakota, 414 E. Clark St., Vermillion, SD 57069, USA. Electronic address: Kathleen.Eyster@usd.edu.
S ApptComparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
A ChalpeDivision of Basic Biomedical Sciences, Sanford School of Medicine of the University of South Dakota, 414 E. Clark St., Vermillion, SD 57069, USA.
T RegisterComparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
T ClarksonComparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
University of South Dakota · US

Funding

Wichozani-A Healthy Lifestyle for Rural American Indian Youth through Cultural and Physical Activities: A Community-Based Participatory Research StudyP20GM103443 · NIGMS · UNIVERSITY OF SOUTH DAKOTA · PI Ryan Michael Johnson · 2012 to 2026
$58.1M
WESTCORE DNA SEQUENCING AND GENOTYPING CORE FACILITYP20RR016479 · NCRR · UNIVERSITY OF SOUTH DAKOTA · PI EICHLER, BARRETT · 2001 to 2011
$32.2M
PSYCHOPHYSIOLOGIC MECHANISMS-ESTROGEN/PROGESTIN EFFECTSP01HL045666 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KAPLAN, JAY R · 1991 to 2004
$10.9M
Role of the Follicle-Depleted Ovary in the Pathogenesis of Chronic DiseasesR01AG027847 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI APPT, SUSAN E · 2006 to 2012
$3.7M
Atherosclerosis Stage, Estrogen Receptors, and Vascular Responses to EstrogenR01AG028641 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI REGISTER, THOMAS COSTIN · 2007 to 2010
$1.2M
NCRR NIH HHS P20 RR016479NHLBI NIH HHS P01 HL045666NHLBI NIH HHS P01 HL45666NIA NIH HHS R01 AG027847NIA NIH HHS R01 AG028641NIA NIH HHS R01 AG27847NIA NIH HHS R01 AG28641NIGMS NIH HHS P20 GM103443
6 · The paper itself

Abstract

BACKGROUND AND

aimsTo examine effects of equol, the soy phytoestrogen metabolite, on gene expression in the monkey iliac artery. METHODS AND

resultsA high fat/high cholesterol diet was fed to eight ovariectomized cynomolgus monkeys for 6.5 years. After biopsy of the left iliac artery, the animals were randomized to two treatment groups for 8 months; the treatment groups were equol (23.7 mg/100 g diet, n = 4) and vehicle (n = 4). The right iliac artery was removed at necropsy. Gene expression in the iliac arteries in response to equol was determined by DNA microarray. Comparison of atherosclerotic lesions and plasma lipids at pre-versus post-equol treatment time points and in vehicle versus equol treatment groups did not identify any significant differences. Despite the lack of effect of equol on these parameters, 59 genes were down-regulated and 279 were up-regulated in response to equol. Comparison of these data to previous work identified 10 genes regulated in opposite directions by equol compared to presence of atherosclerosis plaque (Menopause 2011; 18:1087-1095) and 55 genes differentially expressed in the same direction in response to both equol and estradiol (Eyster et al., Menopause 2014;21:143-152.).

conclusionsSimilar responses of genes to both equol and estradiol may reflect the extent to which equol serves as a natural selective estrogen receptor modulator in the arteries. Opposite responses of 10 genes to equol versus the presence of atherosclerosis implicates those genes in the potential protective effects of equol in arteries.

Indexed as

AnimalsAtherosclerosisDiet, High-FatDisease Models, AnimalEquolFemaleGene Expression RegulationIliac ArteryMacaca fascicularisOvariectomyPhytoestrogensPlaque, AtheroscleroticTime FactorsEquolPhytoestrogensArteryAtherosclerosisDNA microarrayEquolGene expressionSoy

Identifiers

PMID24525253
PMCPMC3972297
OpenAlexW2041510985

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.