Evidence map›Paper›PMID 24525228›Full record

ArticleCancer cell2014

"Atypical" regulation of Hedgehog-dependent cancers.

Scott X Atwood, Anthony E Oro

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Cross-Talk between Wnt and Hh Signaling Pathways in the Pathology of Basal Cell Carcinoma.International journal of environmental research and public health · 2018
    Review
  2. Different Response ofFrontiers in oncology · 2018
    Article
  3. A novel therapeutic approach against B-cell non-Hodgkin's lymphoma through co-inhibition of Hedgehog signaling pathway and autophagy.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016
    Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Scott X AtwoodProgram in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Anthony E OroProgram in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: oro@stanford.edu.

Funding

Leveraging innovative technologies in basic and clinical cancer researchT32CA009302 · NCI · STANFORD UNIVERSITY · PI LAURA D ATTARDI, Aaron M Newman · 1985 to 2026
$19.1M
STROMAL REGULATION OF BASAL CELL CARCINOMA FORMATIONR01AR046786 · NIAMS · STANFORD UNIVERSITY · PI Anthony E Oro · 2001 to 2026
$9.5M
REGULATING GLI FUNCTION IN HAIR FOLLICLE PROGENITORSR01AR054780 · NIAMS · STANFORD UNIVERSITY · PI ORO, ANTHONY E · 2007 to 2017
$4.3M
BEG4/MIM FUNCTION IN EPITHELIAL NEOPLASIAR01AR052785 · NIAMS · STANFORD UNIVERSITY · PI ORO, ANTHONY E · 2007 to 2018
$4.0M
NCI NIH HHS T32 CA009302NIAMS NIH HHS R01 AR046786NIAMS NIH HHS R01 AR052785NIAMS NIH HHS R01 AR054780PHS HHS 5ARO54780PHS HHS ARO46786
6 · The paper itself

Abstract

Growing evidence indicates targeting PKCι may be effective in treating Hedgehog-dependent cancers. In this issue of Cancer Cell, Justilien and colleagues present the surprising finding that PKCι promotes Hedgehog ligand production and lung squamous cell carcinoma growth through SOX2, rather than the canonical transcription factor GLI.

Indexed as

AcyltransferasesAnimalsCarcinoma, Squamous CellCell Transformation, NeoplasticHumansIsoenzymesLung NeoplasmsProtein Kinase CProtein Kinase C-lambdaSOXB1 Transcription FactorsAcyltransferasesHHAT protein, humanIsoenzymesProtein Kinase CProtein Kinase C-lambdaSOX2 protein, humanSOXB1 Transcription Factors

Identifiers

PMID24525228
PMCPMC4024826

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.