Evidence map›Paper›PMID 24524919›Full record

ArticleAJNR. American journal of neuroradiology2014

Phlebographic study does not show differences between patients with MS and control subjects.

M Stefanini, S Fabiano, F Garaci, S Marziali, A Meschini, V Cama, M Fornari, S Rossi, D Centonze, R Gandini and 2 more

Open access · hybridAbstract read
In one paragraph

Article in AJNR. American journal of neuroradiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 82% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

M StefaniniFrom the Departments of Diagnostic Imaging (M.S., S.F., F.G., S.M., A.M., V.C., M.F., R.F., R.G., G.S.).
S FabianoFrom the Departments of Diagnostic Imaging (M.S., S.F., F.G., S.M., A.M., V.C., M.F., R.F., R.G., G.S.) sebas575@yahoo.it.
F GaraciFrom the Departments of Diagnostic Imaging (M.S., S.F., F.G., S.M., A.M., V.C., M.F., R.F., R.G., G.S.).
S MarzialiFrom the Departments of Diagnostic Imaging (M.S., S.F., F.G., S.M., A.M., V.C., M.F., R.F., R.G., G.S.).
A MeschiniFrom the Departments of Diagnostic Imaging (M.S., S.F., F.G., S.M., A.M., V.C., M.F., R.F., R.G., G.S.).
V CamaFrom the Departments of Diagnostic Imaging (M.S., S.F., F.G., S.M., A.M., V.C., M.F., R.F., R.G., G.S.).
M FornariFrom the Departments of Diagnostic Imaging (M.S., S.F., F.G., S.M., A.M., V.C., M.F., R.F., R.G., G.S.).
S RossiNeuroscience (S.R., D.C.), University of Rome Tor Vergata, Rome, ItalySanta Lucia Foundation/European Center for Brain Research (CERC) (S.R., D.C.), Rome, Italy.
D CentonzeNeuroscience (S.R., D.C.), University of Rome Tor Vergata, Rome, ItalySanta Lucia Foundation/European Center for Brain Research (CERC) (S.R., D.C.), Rome, Italy.
R GandiniFrom the Departments of Diagnostic Imaging (M.S., S.F., F.G., S.M., A.M., V.C., M.F., R.F., R.G., G.S.).
G SimonettiFrom the Departments of Diagnostic Imaging (M.S., S.F., F.G., S.M., A.M., V.C., M.F., R.F., R.G., G.S.).
R FlorisFrom the Departments of Diagnostic Imaging (M.S., S.F., F.G., S.M., A.M., V.C., M.F., R.F., R.G., G.S.).
University of Rome Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeHypothetical correlation between chronic cerebrospinal venous insufficiency and MS has gained the attention of patients and the scientific community. Studies performed by echo-color Doppler ultrasonography have shown different results, and it is necessary to use more objective diagnostic techniques. The aim of our study was to evaluate the presence of stenoses affecting azygos veins and internal jugular veins by use of venography in patients with MS. MATERIALS AND

methodsWe recruited 2 groups of subjects who underwent venography: the study group included 29 patients with MS and the control group included 15 healthy volunteers. The ileo-lumbar plexus, the azygos, and the internal jugular veins were selectively catheterized. We considered any cross-sectional area reduction of the venous lumen >50% to be a significant stenosis. Furthermore, blood pressure was measured in the studied vessels at the stenotic internal jugular veins.

resultsSelective venography showed at least 1 significant venous stenosis in 84% of subjects examined, without significant difference between the study group and the control group. Positive venography chronic cerebrospinal venous insufficiency patterns were found in 50% of all subjects examined, without any significant difference between the 2 groups. The multivariate logistic regression analysis failed to assess any significant association between the presence of a positive venography and MS condition. The difference between the median blood pressure of stenotic and nonstenotic internal jugular veins was not statistically significant (P = .46).

conclusionsOur data exclude any direct correlation between chronic cerebrospinal venous insufficiency and MS because venous abnormalities were equally present in both groups.

Indexed as

AdolescentAdultAgedCerebral AngiographyCerebral VeinsDiagnosis, DifferentialFemaleHumansMaleMiddle AgedMultiple SclerosisPhlebographyReference ValuesReproducibility of ResultsSensitivity and SpecificityVenous Insufficiency

Identifiers

PMID24524919
PMCPMC7965159
OpenAlexW2151739487

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.