ArticleBMC genomics2014
Characterisation and expression profile of the bovine cathelicidin gene repertoire in mammary tissue.
Article in BMC genomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 51 citations in OpenAlex.
- Immunomodulatory activities of bovine host defense peptides (HDPs): context-dependent roles in inflammation and immune priming.BMC veterinary research · 2026Article
- Functional genomics of trypanotolerant and trypanosusceptible cattle infected with Trypanosoma congolense across multiple time points and tissues.PLoS neglected tropical diseases · 2025Article
- NF-kappaB is involved exclusively under inflammatory conditions in the regulation of cathelicidin 3 expression in bovine mammary glands through phosphorylation of p65.Journal of animal science · 2025Article
- Bactericidal activities and biochemical features of 16 antimicrobial peptides against bovine-mastitis causative pathogens.Veterinary research · 2024Article
- Synthetic antimicrobial peptides Bac-5, BMAP-28, and Syn-1 can inhibit bovine respiratory disease pathogensFrontiers in veterinary science · 2024Article
- Detection of heat-stable antibacterial activity in cotyledonary and discoid placentas.Placenta · 2023Article
- Analysis of the Effect of Polymorphisms within theJournal of veterinary research · 2023Article
- Novel Alligator Cathelicidin As-CATH8 Demonstrates Anti-Infective Activity against Clinically Relevant and Crocodylian Bacterial Pathogens.Antibiotics (Basel, Switzerland) · 2022Article
- Bovine Immunity and Vitamin DMicroorganisms · 2022Review
- A Novel Proline-Rich Cathelicidin from the AlpacaMembranes · 2022Article
- Dodecapeptide Cathelicidins of Cetartiodactyla: Structure, Mechanism of Antimicrobial Action, and Synergistic Interaction With Other Cathelicidins.Frontiers in microbiology · 2021Article
- Expression Pattern of Cathelicidins in Dairy Cows During Endometritis and Role of Bovine Endometrial Epithelial Cells in Production of Cathelicidins.Frontiers in veterinary science · 2021Article
- Early immune innate hallmarks and microbiome changes across the gut during Escherichia coli O157: H7 infection in cattle.Scientific reports · 2020Article
- Article
- Improved filtration method to isolate pure populations of primary bovine endometrial epithelial and stromal cells for immunological studies.Veterinary research communications · 2020Article
- A Fixed Cohort Field Study of Gene Expression in Circulating Leukocytes From Dairy Cows With and Without Mastitis.Frontiers in veterinary science · 2020Article
- Genomic Identification and Expression Analysis of the Cathelicidin Gene Family of the Forest Musk Deer.Animals : an open access journal from MDPI · 2019Article
- Establishing geneJournal of genetics · 2019Article
- Dietary modulation of endogenous host defense peptide synthesis as an alternative approach to in-feed antibiotics.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2018Review
- Detection and validation of structural variations in bovine whole-genome sequence data.Genetics, selection, evolution : GSE · 2017Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCathelicidins comprise a major group of host-defence peptides. Conserved across a wide range of species, they have several functions related to host defence. Only one cathelicidin has been found in humans but several cathelicidin genes occur in the bovine genome. We propose that these molecules may have a protective role against mastitis. The aim of this study was to characterise the cathelicidin gene-cluster in the bovine genome and to identify sites of expression in the bovine mammary gland.
resultsBioinformatic analysis of the bovine genome (BosTau7) revealed seven protein-coding cathelicidin genes, CATHL1-7, including two identical copies of CATHL4, as well as three additional putative cathelicidin genes, all clustered on the long arm of chromosome 22. Six of the seven protein-coding genes were expressed in leukocytes extracted from milk of high somatic cell count (SCC) cows. CATHL5 was expressed across several sites in the mammary gland, but did not increase in response to Staphylococcus aureus infection.
conclusionsHere, we characterise the bovine cathelicidin gene cluster and reconcile inconsistencies in the datasets of previous studies. Constitutive cathelicidin expression in the mammary gland suggests a possible role for these host defence peptides its protection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.