ReviewClinics in perinatology2014
Neonatal pain control and neurologic effects of anesthetics and sedatives in preterm infants.
Review in Clinics in perinatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 40 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Use of Sedation Drugs in the Procedure of Administering Surfactant Without Intubation (LISA/MIST): a Randomized Study Comparing Intravenous Ketamine With Sublingual 30% Glucose
Use of Premedication for Less Invasive Surfactant Administration: A Randomized Control Trial
Who cites it
40 citing papers in PubMed, 6 syntheses or guidelines pooled it, 107 citations in OpenAlex.
- Changes in the Term Neonatal Electroencephalogram with General Anesthesia: A Systematic Review with Narrative Synthesis.Anesthesiology · 2024Pooled it
- Efficacy and safety of dexmedetomidine for analgesia and sedation in neonates: a systematic review.Journal of perinatology : official journal of the California Perinatal Association · 2024Pooled it
- Guidelines for treatment of acute pain in children - the consensus statement of the Section of Paediatric Anaesthesiology and Intensive Therapy of the Polish Society of Anaesthesiology and Intensive Therapy.Anaesthesiology intensive therapy · 2022Guideline
- Management of pain in newborn circumcision: a systematic review.European journal of pediatrics · 2021Pooled it
- Paracetamol (acetaminophen) for prevention or treatment of pain in newborns.The Cochrane database of systematic reviews · 2020Pooled it
- Paracetamol (acetaminophen) for prevention or treatment of pain in newborns.The Cochrane database of systematic reviews · 2016Pooled it
- Comparison of facilitated tucking and oral dextrose in reducing the pain of heel stick in preterm infants: a randomized clinical trial.BMC pediatrics · 2020Trial
- Neurally adjusted ventilatory assist (NAVA) in preterm newborn infants with respiratory distress syndrome-a randomized controlled trial.European journal of pediatrics · 2016Trial
- Analgosedation in Neonatal Intensive Care: Current Strategies, Challenges, and Future Perspectives.Life (Basel, Switzerland) · 2026Review
- Cumulative exposure to opioids and benzodiazepines in extremely preterm neonates.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Impact of LISA failure on 2-year neurodevelopmental outcomes in preterm infants: a retrospective cohort study.BMJ paediatrics open · 2025Article
- PRG-1 Relieves Neonatal Stimuli-Induced Hyperalgesia and Anxiety via Stage-Specific Synapse Remodeling.CNS neuroscience & therapeutics · 2025Article
- Contextual factors associated with neonatal pain responses: clinical observational study.Frontiers in pediatrics · 2025Article
- Antibiotics, Analgesic Sedatives, and Antiseizure Medications Frequently Used in Critically Ill Neonates: A Narrative Review.Children (Basel, Switzerland) · 2024Review
- Institutional and Regional Variation in Opioid Prescribing for Hospitalized Infants in the US.JAMA network open · 2024Article
- Effect of non-pharmacological interventions on pain in preterm infants in the neonatal intensive care unit: a network meta-analysis of randomized controlled trials.BMC pediatrics · 2024Article
- Application of enhanced recovery after surgery during the perioperative period in children with Meckel's diverticulum-a single-center prospective clinical trial.Frontiers in pediatrics · 2024Article
- Characteristics and outcomes of neonatal opioid withdrawal syndrome in preterm infants: a retrospective cohort study in the current era.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- The Neonatal Withdrawal Assessment Tool (NWAT): pilot inter-rater reliability and content validity.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- The Use of Dexmedetomidine in Preterm Infants: A Single Academic Center Experience.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 3 countries.
Funding
Abstract
Preclinical and clinical studies have demonstrated the adverse consequences of untreated pain and stress on brain development in the preterm infant. Sucrose has widely been implemented as standard therapy for minor procedural pain. Anesthetics are commonly utilized in preterm infants during major surgery. Pharmacologic agents (benzodiazepines and opioids) have been examined in clinical trials of preterm infants requiring invasive mechanical ventilation. Controversy exists regarding the safety and long-term impact of these interventions. Ongoing multidisciplinary research will help define the impact of these agents and identify potential alternative therapies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.