ReviewClinics in perinatology2014
Steroids and injury to the developing brain: net harm or net benefit?
Review in Clinics in perinatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of immune-based interventions for perinatal neuroprotection: closing the gap between animal studies and human trials.Journal of neuroinflammation · 2023Pooled it
- Threshold Effect of Cumulative Postnatal Corticosteroid Dose on Long-Term Outcomes in Extremely Preterm Infants.Journal of clinical medicine · 2026Article
- The shifting landscape of the preterm brain.Neuron · 2025Review
- Perinatal glucocorticoid sensitivity in the preterm newborn: molecular mechanisms, endogenous determinants, and clinical implications.Frontiers in endocrinology · 2025Review
- Betamethasone improved near-term neonatal lamb lung maturation in experimental maternal asthma.Experimental physiology · 2024Article
- Impact of postnatal steroids on peripheral avascular retina and severity of retinopathy of prematurity.Pediatric research · 2023Article
- Preterm lung and brain responses to mechanical ventilation and corticosteroids.Journal of perinatology : official journal of the California Perinatal Association · 2023Review
- The Role of the Interleukin-1 Family in Complications of Prematurity.International journal of molecular sciences · 2023Review
- Continuous Glucose Monitoring in Enterally Fed Children with Severe Central Nervous System Impairment.Nutrients · 2023Observational
- Timing of Systemic Steroids and Neurodevelopmental Outcomes in Infants < 29 Weeks GestationChildren (Basel, Switzerland) · 2022Article
- Systemic Steroids in Preventing Bronchopulmonary Dysplasia (BPD): Neurodevelopmental Outcome According to the Risk of BPD in the EPICE Cohort.International journal of environmental research and public health · 2022Article
- Recent research on the effect of common treatments given in the perinatal period on neurodevelopment in offspring.Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022Review
- Ciclesonide activates glucocorticoid signaling in neonatal rat lung but does not trigger adverse effects in the cortex and cerebellum.Neurobiology of disease · 2021Article
- Drug Use in Pediatric Patients Admitted to Rehabilitation For Severe Acquired Brain Injury: Analysis of the Associations With Rehabilitation Outcomes.Paediatric drugs · 2021Article
- Allogeneic administration of human umbilical cord-derived mesenchymal stem/stromal cells for bronchopulmonary dysplasia: preliminary outcomes in four Vietnamese infants.Journal of translational medicine · 2020Article
- Methylprednisolone Reduces Persistent Post-ischemic Inflammation in a Rat Hypoxia-Ischemia Model of Perinatal Stroke.Translational stroke research · 2020Article
- Antenatal PPAR-γ agonist pioglitazone stimulates fetal lung maturation equally in males and females.American journal of physiology. Lung cellular and molecular physiology · 2020Article
- Computerized Analysis of Brain MRI Parameter Dynamics in Young Patients With Cushing Syndrome-A Case-Control Study.The Journal of clinical endocrinology and metabolism · 2020Article
- Surfactant plus budesonide decreases lung and systemic responses to injurious ventilation in preterm sheep.American journal of physiology. Lung cellular and molecular physiology · 2020Article
- Premature Birth and Developmental Programming: Mechanisms of Resilience and Vulnerability.Frontiers in psychiatry · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Deleterious effects result from both glucocorticoid insufficiency and excess glucocorticoid tissue exposure in the developing brain. Accumulating evidence suggests a net benefit of postnatal glucocorticoid therapy when administered shortly after the first week of life to premature infants with early and persistent pulmonary dysfunction, particularly in those with evidence of relative adrenal insufficiency. The decision to treat with steroids should ensure maximum respiratory benefit at the lowest possible neurologic risk, while avoiding serious systemic complications. Ongoing clinical trials must validate this approach.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.