ArticleDaru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences2014
Effects of rutin on acrylamide-induced neurotoxicity.
Article in Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 67 citations in OpenAlex.
- Ameliorative effects of Crocin as a potent antioxidant with its spectral characterization against Cadmium chloride-induced hepatotoxicity.Scientific reports · 2026Article
- Cannabidiol as a Neuroprotective Agent in Acrylamide-Induced Neurotoxicity: Effects on Oxidative Stress, Inflammation, and Cholinergic Function in Male Mice.Journal of neuroscience research · 2025Article
- Molecular mechanisms of neuroprotective effect of rutin.Frontiers in pharmacology · 2025Review
- Bisphosphonate's effect on the tongue in adult male albino rats and the possible protective role of rutin: light and scanning electron microscopic study.Anatomy & cell biology · 2024Article
- Blueberry Anthocyanins Extract Attenuates Acrylamide-Induced Oxidative Stress and Neuroinflammation in Rats.Oxidative medicine and cellular longevity · 2022Article
- A Novel Approach to Unraveling the Apoptotic Potential of Rutin (Bioflavonoid) via TargetingMolecules (Basel, Switzerland) · 2021Article
- Saussureae Involucratae Herba (Snow Lotus): Review of Chemical Compositions and Pharmacological Properties.Frontiers in pharmacology · 2019Review
- Ameliorative effects of rutin against cisplatin-induced reproductive toxicity in male rats.BMC urology · 2018Article
- Olive oil abrogates acrylamide induced nephrotoxicity by modulating biochemical and histological changes in rats.Renal failure · 2017Article
- Treatment with Rutin - A Therapeutic Strategy for Neutrophil-Mediated Inflammatory and Autoimmune Diseases: - Anti-inflammatory Effects of Rutin on Neutrophils.Journal of pharmacopuncture · 2017Article
- Protective effect of rosemary on acrylamide motor neurotoxicity in spinal cord of rat offspring: postnatal follow-up study.Anatomy & cell biology · 2016Article
- An up-to-date review of rutin and its biological and pharmacological activities.EXCLI journal · 2015Article
- Concomitant administration of resveratrol and resistance training ameliorates acrylamide-induced spatial learning impairment in rats.Avicenna journal of phytomedicineArticle
- Article
- Evaluating the effect of rutin on contrast-induced nephropathy in rats.Avicenna journal of phytomedicineArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRutin is an important flavonoid that is consumed in the daily diet. The cytoprotective effects of rutin, including antioxidative, and neuroprotective have been shown in several studies. Neurotoxic effects of acrylamide (ACR) have been established in humans and animals. In this study, the protective effects of rutin in prevention and treatment of neural toxicity of ACR were studied.
resultsRutin significantly reduced cell death induced by ACR (5.46 mM) in time- and dose-dependent manners. Rutin treatment decreased the ACR-induced cytotoxicity significantly in comparison to control (P <0.01, P < 0.001). Rutin (100 and 200 mg/kg) could prevent decrease of body weight in rats. In combination treatments with rutin (50, 100 and 200 mg/kg), vitamin E (200 mg/kg) and ACR, gait abnormalities significantly decreased in a dose-dependent manner (P < 0.01 and P < 0.001). The level of malondialdehyde significantly decreased in the brain tissue of rats in both preventive and therapeutic groups that received rutin (100 and 200 mg/kg).
conclusionIt seems that rutin could be effective in reducing neurotoxicity and the neuroprotective effect of it might be mediated via antioxidant activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.