ArticleBMC gastroenterology2014
Effect of gluten free diet on immune response to gliadin in patients with non-celiac gluten sensitivity.
Article in BMC gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Crossover Trial of Purified Gluten and Whole Wheat (Gluten With Amylase-trypsin Inhibitors) as Triggers of Gastrointestinal Symptoms in Patients With Irritable Bowel Syndrome
Clinical Characteristics and Pathogenic Mechanisms of Anemia in Non-celiac Wheat Sensitivity Compared to Celiac Disease and Irritable Bowel Syndrome
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.
- Mood Disorders and Gluten: It's Not All in Your Mind! A Systematic Review with Meta-Analysis.Nutrients · 2018Pooled it
- Psychiatric Symptoms Associated with Non-Celiac Gluten Sensitivity: A Focused Narrative Review.Nutrients · 2026Review
- Observational
- Review
- Factors Affecting Gluten-Free Dietary Adherence in Patients with Neurological Gluten-Related Disease.Nutrients · 2026Article
- Non-Coeliac Wheat Sensitivity: Symptoms in Search of a Mechanism, or a Distinct Well-Defined Clinical Entity? A Narrative Review.International journal of molecular sciences · 2025Review
- Review
- Autoantibodies related to ataxia and other central nervous system manifestations of gluten enteropathy.World journal of clinical cases · 2024Review
- Gluten and Autism Spectrum Disorder.Nutrients · 2021Review
- Effect of Gluten-Free Diet on Gut Microbiota Composition in Patients with Celiac Disease and Non-Celiac Gluten/Wheat Sensitivity.Nutrients · 2020Review
- Pathogenesis of Celiac Disease and Other Gluten Related Disorders in Wheat and Strategies for Mitigating Them.Frontiers in nutrition · 2020Review
- Bridging the Gap Between Physical Health and Autism Spectrum Disorder.Neuropsychiatric disease and treatment · 2020Review
- Non-Celiac Gluten Sensitivity: A Review.Medicina (Kaunas, Lithuania) · 2019Review
- Nonceliac Wheat Sensitivity: An Immune-Mediated Condition with Systemic Manifestations.Gastroenterology clinics of North America · 2019Review
- Exit Gluten-Free and Enter Low FODMAPs: A Novel Dietary Strategy to Reduce Gastrointestinal Symptoms in Athletes.Sports medicine (Auckland, N.Z.) · 2019Review
- Gluten and Functional Abdominal Pain Disorders in Children.Nutrients · 2018Review
- Cognitive Impairment and Celiac Disease: Is Transcranial Magnetic Stimulation aInternational journal of molecular sciences · 2018Review
- Biological markers for non-celiac gluten sensitivity: a question awaiting for a convincing answer.Gastroenterology and hepatology from bed to bench · 2018Review
- Review
- Non-celiac gluten sensitivity: All wheat attack is not celiac.World journal of gastroenterology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNon-celiac gluten sensitivity is a syndrome characterized by gastrointestinal and extra-intestinal symptoms occurring in a few hours/days after gluten and/or other wheat protein ingestion and rapidly improving after exclusion of potential dietary triggers. There are no established laboratory markers for non-celiac gluten sensitivity, although a high prevalence of first generation anti-gliadin antibodies of IgG class has been reported in this condition. This study was designed to characterize the effect of the gluten-free diet on anti-gliadin antibodies of IgG class in patients with non-celiac gluten sensitivity.
methodsAnti-gliadin antibodies of both IgG and IgA classes were assayed by ELISA in 44 non-celiac gluten sensitivity and 40 celiac disease patients after 6 months of gluten-free diet.
resultsThe majority of non-celiac gluten sensitivity patients (93.2%) showed the disappearance of anti-gliadin antibodies of IgG class after 6 months of gluten-free diet; in contrast, 16/40 (40%) of celiac patients displayed the persistence of these antibodies after gluten withdrawal. In non-celiac gluten sensitivity patients anti-gliadin antibodies IgG persistence after gluten withdrawal was significantly correlated with the low compliance to gluten-free diet and a mild clinical response.
conclusionsAnti-gliadin antibodies of the IgG class disappear in patients with non-celiac gluten sensitivity reflecting a strict compliance to the gluten-free diet and a good clinical response to gluten withdrawal.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.