Evidence map›Paper›PMID 24524345›Full record

ArticleItalian journal of pediatrics2014

Cytophagic histiocytic panniculitis, hemophagocytic lymphohistiocytosis and undetermined autoimmune disorder: reconciling the puzzle.

Claudia Pasqualini, Mauro Jorini, Ines Carloni, Mirella Giangiacomi, Valentina Cetica, Maurizio Aricò, Fernando Maria de Benedictis

Open access · goldAbstract readCase Reports
In one paragraph

Article in Italian journal of pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Claudia Pasqualini
Mauro Jorini
Ines Carloni
Mirella Giangiacomi
Valentina Cetica
Maurizio Aricò
Fernando Maria de BenedictisDepartment of Mother and Child Health, Azienda Ospedaliero-Universitaria, Ancona, Italy. debenedictis@ospedaliriuniti.marche.it.
Azienda Ospedaliero Universitaria Ospedali Riuniti · ITMeyer Children's Hospital · ITTumour Institute of Tuscany · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytophagic histiocytic panniculitis is a rare disease, associated with either nonmalignant conditions or subcutaneous panniculitis-like T-cell lymphoma, and often also associated with hemophagocytic lymphohistiocytosis (HLH). We report the case of a 11-year-old boy with a history of secondary HLH who, after a local trauma, developed a painful, indurated plaque over the right thigh associated with relapsing HLH. Histopathologic findings from skin biopsy specimens revealed significant lobular panniculitis with benign histiocytes showing hemophagocytosis. High-dose intravenous methylprednisolone and cyclosporine A treatment was highly effective. A genetic study after a new, relapsing episode of HLH revealed an heterozygous missense mutation on STX 11 gene inherited from the mother.

Indexed as

Autoimmune DiseasesBiopsyChildDiagnosis, DifferentialFollow-Up StudiesGenetic TestingHumansLymphohistiocytosis, HemophagocyticLymphoma, T-CellMalePanniculitisSkin

Identifiers

PMID24524345
PMCPMC3974103
OpenAlexW1975010675

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.