ArticleBMC neuroscience2014
Mitochondrial oxygen consumption deficits in skeletal muscle isolated from an Alzheimer's disease-relevant murine model.
Article in BMC neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed, 36 citations in OpenAlex.
- Nervonic acid and 15-epi-PGA1 mediate systemic mitochondrial dysfunction in AD dementia.GeroScience · 2026Article
- Mitochondrial Metabolic Reprogramming of Cortical Neurons by Prenatal Exposure to Corticosterone: A Shift from ATP Synthesis to Membrane Potential Maintenance.Experimental neurobiology · 2026Article
- Factors associated with motor manifestations in older adults with Alzheimer's dementia: a cross-sectional analysis.European geriatric medicine · 2025Article
- Alzheimer's Disease: Understanding Motor Impairments.Brain sciences · 2024Review
- Naringenin ameliorates amyloid-β pathology and neuroinflammation in Alzheimer's disease.Communications biology · 2024Article
- Effects and mechanisms of APP and its cleavage product Aβ in the comorbidity of sarcopenia and Alzheimer's disease.Frontiers in aging neuroscience · 2024Review
- APP in the Neuromuscular Junction for the Development of Sarcopenia and Alzheimer's Disease.International journal of molecular sciences · 2023Review
- Prevalence and Mechanisms of Skeletal Muscle Atrophy in Metabolic Conditions.International journal of molecular sciences · 2023Review
- Synergistic Effect ofNutrients · 2023Article
- Peripapillary Oxygenation and Retinal Vascular Responsiveness to Flicker Light in Primary Open Angle Glaucoma.Metabolites · 2022Article
- Regulation of NADMetabolism: clinical and experimental · 2022Review
- Age Related Changes in Muscle Mass and Force Generation in the Triple Transgenic (3xTgAD) Mouse Model of Alzheimer's Disease.Frontiers in aging neuroscience · 2022Article
- Article
- Mild Cognitive Impairment and Donepezil Impact Mitochondrial Respiratory Capacity in Skeletal Muscle.Function (Oxford, England) · 2021Article
- Can the Energetic Profile of Skeletal Muscle Predict Risk of Cognitive Impairment?Function (Oxford, England) · 2021Article
- Heat therapy: possible benefits for cognitive function and the aging brain.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Review
- An Exploratory Analysis of Potential New Biomarkers of Cognitive Function.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- MH84 improves mitochondrial dysfunction in a mouse model of early Alzheimer's disease.Alzheimer's research & therapy · 2018Article
- Simple and inexpensive technique for measuring oxygen consumption rate in adherent cultured cells.The journal of physiological sciences : JPS · 2017Article
- Genetic ablation of the p66Molecular psychiatry · 2017Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundAge is considered a primary risk factor for neurodegenerative diseases including Alzheimer's disease (AD). It is also now well understood that mitochondrial function declines with age. Mitochondrial deficits have been previously assessed in brain from both human autopsy tissue and disease-relevant transgenic mice. Recently it has been recognized that abnormalities of muscle may be an intrinsic aspect of AD and might contribute to the pathophysiology. However, deficits in mitochondrial function have yet to be clearly assessed in tissues outside the central nervous system (CNS). In the present study, we utilized a well-characterized AD-relevant transgenic mouse strain to assess mitochondrial respiratory deficits in both brain and muscle. In addition to mitochondrial function, we assessed levels of transgene-derived amyloid precursor protein (APP) in homogenates isolated from brain and muscle of these AD-relevant animals.
resultsWe now demonstrate that skeletal muscles isolated from these animals have differential levels of mutant full-length APP depending on muscle type. Additionally, isolated muscle fibers from young transgenic mice (3 months) have significantly decreased maximal mitochondrial oxygen consumption capacity compared to non-transgenic, age-matched mice, with similar deficits to those previously described in brain.
conclusionsThis is the first study to directly examine mitochondrial function in skeletal muscle from an AD-relevant transgenic murine model. As with brain, these deficits in muscle are an early event, occurring prior to appearance of amyloid plaques.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.