ArticleBioMed research international2014
Systemic oxidative stress and conversion to dementia of elderly patients with mild cognitive impairment.
Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 62 citations in OpenAlex.
- The Effects of FermentedEvidence-based complementary and alternative medicine : eCAM · 2018Trial
- Resveratrol Supplementation Modulates Endothelial Dysfunction in Alzheimer's Disease (AD):Current neuropharmacology · 2026Article
- Oxidative Stress Biomarkers as Preclinical Markers of Mild Cognitive Impairment: The Impact of Age and Sex.Journal of personalized medicine · 2025Article
- Trajectory of Cardiogenic Dementia: A New Perspective.Journal of cellular and molecular medicine · 2025Review
- Chronic cerebral hypoperfusion: a critical feature in unravelling the etiology of vascular cognitive impairment.Acta neuropathologica communications · 2023Review
- GlyNAC (Glycine and N-Acetylcysteine) Supplementation in Old Mice Improves Brain Glutathione Deficiency, Oxidative Stress, Glucose Uptake, Mitochondrial Dysfunction, Genomic Damage, Inflammation and Neurotrophic Factors to Reverse Age-Associated Cognitive Decline: Implications for Improving Brain Health in Aging.Antioxidants (Basel, Switzerland) · 2023Article
- The Neuroprotective Potentiality of Flavonoids on Alzheimer's Disease.International journal of molecular sciences · 2022Review
- Activation of arginase II by asymmetric dimethylarginine and homocysteine in hypertensive rats induced by hypoxia: a new model of nitric oxide synthesis regulation in hypertensive processes?Hypertension research : official journal of the Japanese Society of Hypertension · 2021Review
- Salivary Redox Biomarkers in Selected Neurodegenerative Diseases.Journal of clinical medicine · 2020Review
- Serum beta-secretase 1 (BACE1) activity as candidate biomarker for late-onset Alzheimer's disease.GeroScience · 2020Article
- Cognitive-Enhancing,Biochemistry research international · 2020Article
- Early Detection and Prevention of Alzheimer's Disease: Role of Oxidative Markers and Natural Antioxidants.Frontiers in aging neuroscience · 2020Review
- Article
- Changes in Adipose Tissue Distribution and Association between Uric Acid and Bone Health during Menopause Transition.International journal of molecular sciences · 2019Article
- Reasons for Failed Trials of Disease-Modifying Treatments for Alzheimer Disease and Their Contribution in Recent Research.Biomedicines · 2019Review
- Evaluating the link between Paraoxonase-1 levels and Alzheimer's disease development.Minerva medica · 2019Review
- Oxidative stress in cervical cancer and its response to chemoradiation.Turkish journal of obstetrics and gynecology · 2019Article
- Testing a Combination of Markers of Systemic Redox Status as a Possible Tool for the Diagnosis of Late Onset Alzheimer's Disease.Disease markers · 2018Article
- Antioxidant Defence, Oxidative Stress and Oxidative Damage in Saliva, Plasma and Erythrocytes of Dementia Patients. Can Salivary AGE be a Marker of Dementia?International journal of molecular sciences · 2017Article
- Preliminary Data on the Interaction between Some Biometals and Oxidative Stress Status in Mild Cognitive Impairment and Alzheimer's Disease Patients.Oxidative medicine and cellular longevity · 2017Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mild cognitive impairment (MCI) is regarded as a prodromal phase of late onset Alzheimer's disease (LOAD). It has been proposed that oxidative stress (OxS) might be implicated in the pathogenesis of LOAD. The aim of this study was to investigate whether a redox imbalance measured as serum level of hydroperoxides (i.e., by-products of lipid peroxidation) and/or serum antioxidant capacity might be predictive of the clinical progression of MCI to LOAD. The levels of these two markers were measured in 111 patients with MCI (follow-up: 2.0 ± 0.6 years), 105 patients with LOAD, and 118 nondemented healthy controls. Multivariate analysis adjusted for potential confounding factors, including age, gender, smoking, and comorbidities, showed a significant increase (P < 0.05) in baseline levels of OxS in MCI and LOAD as compared to cognitive healthy controls. No differences in either of OxS markers were found by comparing MCI patients who converted (n = 29) or not converted (n = 82) to LOAD. Overall, these results suggest that systemic OxS might be a precocious feature of MCI and LOAD. However, the role of OxS as an early prognostic marker of progression to LOAD needs further investigations.
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