Evidence map›Paper›PMID 24524012›Full record

ArticleCurrent nutrition reports2013

What We Know About Diet, Genes, and Dyslipidemia: Is There Potential for Translation?

Toni I Pollin, Michael Quartuccio

Open access · bronzeAbstract read
In one paragraph

Article in Current nutrition reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

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  14. Therapeutic potential ofAvicenna journal of phytomedicine
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Toni I PollinDepartment of Medicine, University of Maryland School of Medicine, Baltimore, Maryland ; Program in Genetics and Genomic Medicine, Department of Epidemiology & Public Health, University of Maryland School of Medicine, Baltimore, Maryland.
Michael QuartuccioDepartment of Medicine, University of Maryland School of Medicine, Baltimore, Maryland.
University of Maryland, Baltimore · US

Funding

JHU-UMD Diabetes Research CenterP30DK079637 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI AHIMA, REXFORD S. · 2013 to 2017
$9.7M
Fine-mapping and Characterization of Metabolic Loci in the DPP Outcomes StudyR01DK072041 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI FLOREZ, JOSE CARLOS · 2005 to 2017
$7.6M
The Metabolic Impact of Congenital Heterozygous ApoC-III Deficiency in HumansR01HL104193 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI POLLIN, TONI I. · 2011 to 2015
$3.0M
NHLBI NIH HHS R01 HL104193NIDDK NIH HHS P30 DK079637NIDDK NIH HHS R01 DK072041
6 · The paper itself

Abstract

Cardiovascular disease, particularly coronary artery disease (CAD), is the leading cause of death in the United States. Dyslipidemia, including elevated low density lipoprotein cholesterol (LDL-C) and triglyceride (TG) levels and low high density lipoprotein cholesterol (HDL-C), is a well-established risk factor for CAD and is influenced by both genetic and lifestyle factors, including the diet and dietary fat in particular. Major strides in elucidating the genetic basis for dyslipidemia have been made in recent years, and the quest to clarify how genetic differences influence lipid response to dietary intervention continues. Some monogenic conditions such as famililal hypercholesterolemia and sitosterolemia already have customized dietary recommendations. Some promising associations have emerged for more polygenic dyslipidemia, but further studies are needed in large dietary intervention studies capturing increasing amounts of explainable genetic variation before recommendations can be made for clinical translation.

Indexed as

cholesteroldietary fatdietary intervention studiesgene-diet interactionsgeneticsmonounsaturated fatnutrigenomicspolyunsaturated fattriglycerides

Identifiers

PMID24524012
PMCPMC3918461
OpenAlexW2087908229

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.