ArticleISRN biochemistry2013
Cellular and Biochemical Mechanisms of the Retroviral Restriction Factor SAMHD1.
Article in ISRN biochemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 19 citations in OpenAlex.
- Aggravating mechanisms from COVID-19.Virology journal · 2024Review
- HIV-1 restriction by SERINC5.Medical microbiology and immunology · 2023Review
- SAMHD1 Impairs HIV-1 Gene Expression and Negatively Modulates Reactivation of Viral Latency in CD4Journal of virology · 2018Article
- SAMHD1 suppresses innate immune responses to viral infections and inflammatory stimuli by inhibiting the NF-κB and interferon pathways.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- A Cyclin-Binding Motif in Human SAMHD1 Is Required for Its HIV-1 Restriction, dNTPase Activity, Tetramer Formation, and Efficient Phosphorylation.Journal of virology · 2018Article
- Nucleic Acid Immunity.Advances in immunology · 2017Article
- The ubiquitin ligase TRIM27 functions as a host restriction factor antagonized by Mycobacterium tuberculosis PtpA during mycobacterial infection.Scientific reports · 2016Article
- SAMHD1 controls cell cycle status, apoptosis and HIV-1 infection in monocytic THP-1 cells.Virology · 2016Article
- Article
- Regulation of deoxynucleotide metabolism in cancer: novel mechanisms and therapeutic implications.Molecular cancer · 2015Review
- SAMHD1's protein expression profile in humans.Journal of leukocyte biology · 2015Article
- Role of myeloid cells in HIV-1-host interplay.Journal of neurovirology · 2015Review
- HIV-2 infects resting CD4+ T cells but not monocyte-derived dendritic cells.Retrovirology · 2015Article
- Structural basis of allosteric activation of sterile α motif and histidine-aspartate domain-containing protein 1 (SAMHD1) by nucleoside triphosphates.The Journal of biological chemistry · 2014Article
- Structural basis of cellular dNTP regulation by SAMHD1.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Identification of cellular proteins interacting with the retroviral restriction factor SAMHD1.Journal of virology · 2014Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Replication of HIV-1 and other retroviruses is dependent on numerous host proteins in the cells. Some of the host proteins, however, function as restriction factors to block retroviral infection of target cells. The host protein SAMHD1 has been identified as the first mammalian deoxynucleoside triphosphate triphosphohydrolase (dNTPase), which blocks the infection of HIV-1 and other retroviruses in non-cycling immune cells. SAMHD1 protein is highly expressed in human myeloid-lineage cells and CD4
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.