ArticlePloS one2014
Failure to detect functional neutrophil B helper cells in the human spleen.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Beyond host defense and tissue injury: the emerging role of neutrophils in tissue repair.American journal of physiology. Cell physiology · 2024Review
- A Flow Cytometry-Based High-Throughput Technique for Screening Integrin-Inhibitory Drugs.Journal of visualized experiments : JoVE · 2024Article
- Neutrophils in homeostasis and tissue repair.International immunology · 2022Review
- Neutrophils in secondary lymphoid organs.Immunology · 2021Review
- Review
- Neutrophil Diversity in Health and Disease.Trends in immunology · 2019Review
- Review
- Neutrophil Heterogeneity as Therapeutic Opportunity in Immune-Mediated Disease.Frontiers in immunology · 2019Review
- Expression, Role, and Regulation of Neutrophil Fcγ Receptors.Frontiers in immunology · 2019Review
- Article
- Red pulp macrophages in the human spleen are a distinct cell population with a unique expression of Fc-γ receptors.Blood advances · 2018Article
- Human and murine splenic neutrophils are potent phagocytes of IgG-opsonized red blood cells.Blood advances · 2017Article
- Splenic Ly6GThe Journal of experimental medicine · 2017Article
- Strategies to Improve Vaccine Efficacy against Tuberculosis by Targeting Innate Immunity.Frontiers in immunology · 2017Review
- Human memory B cells.Leukemia · 2016Review
- Neutrophils trigger a NF-κB dependent polarization of tumor-supportive stromal cells in germinal center B-cell lymphomas.Oncotarget · 2015Article
- Neutrophils: Between host defence, immune modulation, and tissue injury.PLoS pathogens · 2015Review
- Functional capacities of human IgM memory B cells in early inflammatory responses and secondary germinal center reactions.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- How Neutrophils Shape Adaptive Immune Responses.Frontiers in immunology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A novel role for human neutrophilic granulocytes was recently described, showing that these cells, upon entering the spleen, can be reprogrammed into a distinct B cell-helper neutrophil phenotype that is capable of eliciting B cell responses such as immunoglobulin secretion, class switch recombination and somatic hypermutation. Using similar protocols, we detected a homogeneous population of CD15(high)CD16(high) neutrophils in fresh human spleen samples, which did not differ in phenotype and function from blood neutrophils. No phenotypic characteristics of costimulatory nature were detected on splenic or circulating neutrophils, nor could we reproduce the immunoglobulin production of splenic B cells in the presence of splenic neutrophils, although B cell function and neutrophil activity were normal. Independent confirmation of a role for NBH cells is required.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.